Calcineurin-Inhibitor Induced Pain Syndrome in a Heart Transplant Patient.

Calcineurin-Inhibitor Induced Pain Syndrome in a Heart Transplant Patient.
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DOI:
10.1016/j.transproceed.2021.08.014
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发表时间:
2021-10
影响因子:
0.9
通讯作者:
Guglin M
Guglin M
中科院分区:
医学4区
文献类型:
--
作者:
Ilonze OJ;Giovannini M;Jones MA;Rao R;Ballut K;Guglin M

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钙调神经磷酸酶抑制剂诱导的疼痛综合征(CIPS)也称为“对称性骨综合征”,是一种描述接受钙调神经磷酸酶抑制剂(尤其是他克莫司)的器官移植后患者的可逆性下肢疼痛的病症。我们报告一例原位心脏移植术后并发严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)感染的CIPS。我们强调的介绍,诊断评估和结果。然后,我们讨论了CIPS的病理生理机制,并总结了管理策略的讨论。此外,我们提出了一个表格,以指导临床医生评估移植后骨痛综合征。据我们所知,这是第一篇文章描述了CIPS并发SARS-CoV-2感染的病例。
Calcineurin-inhibitor induced pain syndrome (CIPS) also called the “symmetrical bone syndrome” is a condition describing reversible lower extremity pain in patients after organ transplantation who are receiving calcineurin inhibitors, especially tacrolimus. We present a case of CIPS after orthotopic heart transplant complicated with concurrent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We emphasize the presentation; diagnostic evaluation, and findings. We then discuss the proposed pathophysiologic mechanisms of CIPS and conclude with discussion of management strategies. Additionally, we present a table to guide clinicians in assessing posttransplant bone pain syndromes. To our knowledge, this is the first article to describe a case of CIPS with concurrent SARS-CoV-2 infection.
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