Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients.
Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients.
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DOI：
10.18632/oncotarget.9623
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发表时间：
2017-09-01
期刊：
影响因子：
--
通讯作者：
Sun XF
中科院分区：
文献类型：
--
作者：
Liu N;Cox TR;Cui W;Adell G;Holmlund B;Ping J;Jarlsfelt I;Erler JT;Sun XF
新的证据表明赖氨酰氧化酶 (LOX) 在癌症进展和转移中发挥着关键作用。虽然大多数工作都集中在 LOX 的细胞外基质交联作用上，但细胞内 LOX 定位的确切功能仍不清楚。在本研究中，我们分析了直肠癌患者样本细胞核中的 LOX 表达模式，并确定了该表达的临床意义。与原发肿瘤相比，患者淋巴结转移中的核 LOX 表达显着增加。肿瘤中高核LOX表达与高远处转移率和复发率增加相关。多变量分析表明，高核 LOX 表达还与较差的总生存期和无病生存期相关。此外，我们首次通过共聚焦显微镜和蛋白质印迹鉴定结肠癌细胞系细胞核内的 LOX 酶亚型（50 kDa 和 32 kDa）。我们的结果表明肿瘤中核 LOX 表达与患者生存之间存在密切联系，并为直肠癌患者提供了一种有前景的预后生物标志物。
Emerging evidence has implicated a pivotal role for lysyl oxidase (LOX) in cancer progression and metastasis. Whilst the majority of work has focused on the extracellular matrix cross-linking role of LOX, the exact function of intracellular LOX localisation remains unclear. In this study, we analysed the LOX expression patterns in the nuclei of rectal cancer patient samples and determined the clinical significance of this expression. Nuclear LOX expression was significantly increased in patient lymph node metastases compared to their primary tumours. High nuclear LOX expression in tumours was correlated with a high rate of distant metastasis and increased recurrence. Multivariable analysis showed that high nuclear LOX expression was also correlated with poor overall survival and disease free survival. Furthermore, we are the first to identify LOX enzyme isoforms (50 kDa and 32 kDa) within the nucleus of colon cancer cell lines by confocal microscopy and Western blot. Our results show a powerful link between nuclear LOX expression in tumours and patient survival, and offer a promising prognostic biomarker for rectal cancer patients.
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影响因子：
2.4
作者：
Lewander A;Gao J;Adell G;Zhang H;Sun XF
通讯作者：
Sun XF
影响因子：
6.4
作者：
Albinger-Hegyi, Andrea;Stoeckli, Sandro J.;Hegyi, Ivan
通讯作者：
Hegyi, Ivan
影响因子：
3.4
作者：
Chung EJ;Hudak K;Horton JA;White A;Scroggins BT;Vaswani S;Citrin D
通讯作者：
Citrin D
影响因子：
64.8
作者：
Cox TR;Rumney RMH;Schoof EM;Perryman L;Høye AM;Agrawal A;Bird D;Latif NA;Forrest H;Evans HR;Huggins ID;Lang G;Linding R;Gartland A;Erler JT
通讯作者：
Erler JT
影响因子：
8
作者：
Palamakumbura, A. H.;Vora, S. R.;Nugent, M. A.;Kirsch, K. H.;Sonenshein, G. E.;Trackman, P. C.
通讯作者：
Trackman, P. C.