Improvement of Low Luminance Visual Acuity in Patients with Chronic Central Serous Chorioretinopathy after Half-Dose Verteporfin Photodynamic Therapy.
Improvement of Low Luminance Visual Acuity in Patients with Chronic Central Serous Chorioretinopathy after Half-Dose Verteporfin Photodynamic Therapy.
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半剂量维替泊芬光动力疗法对慢性中心性浆液性脉络膜视网膜病变患者低亮度视力的改善
DOI：
10.3390/jcm9123980
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发表时间：
2020-12-09
影响因子：
3.9
通讯作者：
Oda K
中科院分区：
文献类型：
--
作者：
Fujita K;Shinoda K;Imamura Y;Matsumoto CS;Oda K
中心性浆液性脉络膜视网膜病变(CSC)患者经常抱怨在低亮度条件下视力困难。在这项研究中，我们评估了半剂量维替普芬光动力疗法(HdPDT)治疗CSC后的低亮度视力(LIVA)。这项研究包括8名接受hdPDT的慢性CSC患者的8只眼。分别于术前、术后1、3、6、9和12个月评估最佳矫正视力、LIVA和光学相干断层扫描(OCT)结果。在六种背景亮度水平下测量LIVA。浆液性视网膜脱离全部治愈。尽管在所有亮度水平下，1个月的平均LIVA与基线相比没有显著改善，但在3、6、9和12个月时观察到显著的改善(p<；0.05)。在OCT图像中，虽然在hdPDT前所有眼都没有发现椭圆形带，但在1个月时2只眼，3个月时7只眼，6个月后所有眼都能观察到椭圆形带。随着术后时间的延长，LIVA和椭圆区的改善相似。综上所述，hdPDT改善了慢性CSC眼的LIVA。椭圆区的恢复可能在hdPDT后LIVA的改善中起一定作用。
Patients with central serous chorioretinopathy (CSC) often complain of visual difficulties under low luminance conditions. In this study, we evaluated low luminance visual acuity (LLVA) after half-dose verteporfin photodynamic therapy (hdPDT) in eyes with CSC. The study included eight eyes of eight patients with chronic CSC that underwent hdPDT. The best-corrected visual acuity, LLVA and optical coherence tomography (OCT) findings were evaluated at baseline, and at 1, 3, 6, 9, and 12 months after hdPDT. LLVA was measured at six levels of background luminance. Serous retinal detachment was completely resolved in all eyes. Although the mean LLVA at 1 month did not improve significantly compared to baseline at all luminance levels, significant improvements were observed at 3, 6, 9, and 12 months (p < 0.05). In OCT images, although the ellipsoid zone was not detectable in all eyes before hdPDT, it was observed in 2 eyes at 1 month, in 7 eyes at 3 months, and in all eyes from 6 months. The LLVA and the ellipsoid zone improved similarly with postoperative time courses. In conclusion, hdPDT improves LLVA in eyes with chronic CSC. The recovery of the ellipsoid zone may play a part in improving LLVA after hdPDT.
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DOI：
10.1085/jgp.21.2.165
发表时间：
1937-11-20
期刊：
The Journal of general physiology
影响因子：
--
作者：
Shlaer S
通讯作者：
Shlaer S
DOI：
10.1097/iae.0000000000000027
发表时间：
2014-05-01
影响因子：
3.3
作者：
Fujita, Kyoko;Imamura, Yutaka;Yuzawa, Mitsuko
通讯作者：
Yuzawa, Mitsuko
影响因子：
4.2
作者：
Piccolino, FC;De La Longrais, RR;Manea, M
通讯作者：
Manea, M
影响因子：
4.4
作者：
Welker, Susanne G;Pfau, Maximilian;Finger, Robert P
通讯作者：
Finger, Robert P
影响因子：
4.1
作者：
Chan, WM;Lam, DSC;Chan, CKM
通讯作者：
Chan, CKM