A multimeric MR-optical contrast agent for multimodal imaging.

A multimeric MR-optical contrast agent for multimodal imaging.
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DOI:
10.1039/c4cc05651e
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发表时间:
2014-10-09
期刊:
Chemical communications (Cambridge, England)
影响因子:
--
通讯作者:
Meade TJ
Meade TJ
中科院分区:
其他
文献类型:
--
作者:
Harrison VS;Carney CE;Macrenaris KW;Meade TJ

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我们描述了一种多模式和多聚体造影剂的设计、合成和体外评价。该试剂由三个大环Gd(III)螯合物与荧光团缀合组成,具有高弛豫率、水溶性和无毒。模块化合成适合于掺入各种荧光团以生成用于多种应用的分子构建体。
We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores to generate molecular constructs for a number of applications.
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