Inflammation and implantation.
Inflammation and implantation.
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DOI：
10.1111/j.1600-0897.2009.00792.x
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Mor G
中科院分区：
文献类型：
--
作者：
Dekel N;Gnainsky Y;Granot I;Mor G
大约一半的人类胚胎移植导致妊娠失败。多种因素可能导致这种失败，包括胚胎的遗传或代谢异常。然而，许多这些自发性早期流产病例是由于子宫容受性差。此外，尽管许多生育障碍已被各种辅助生殖技术克服，但植入仍然是体外受精（IVF）治疗成功的限速步骤。已经证明，在自发的、前一周期或IVF周期本身期间进行的子宫内膜活检显著提高了着床率、临床妊娠率和活产率。这些观察结果表明，子宫内膜的机械损伤可能通过刺激免疫系统产生炎症反应来增强子宫容受性。为了有力地支持这一观点，我们最近发现，树突状细胞（DC），先天免疫系统的重要细胞成分，在小鼠模型中成功植入中起着关键作用。在这篇综述中，我们讨论了这样的假设，即活检治疗的患者中的损伤衍生的炎症产生了子宫DC积聚的焦点，这反过来又增强了子宫内膜中必需分子的表达，从而促进了胚胎和子宫上皮之间的相互作用。
Approximately half of all human embryo implantations result in failed pregnancy. Multiple factors may contribute to this failure, including genetic or metabolic abnormalities of the embryo. However, many of these spontaneous early abortion cases are attributed to poor uterine receptivity. Furthermore, although many fertility disorders have been overcome by a variety of assisted reproductive techniques, implantation remains the rate-limiting step for the success of the in vitro fertilization (IVF) treatments. It has been demonstrated that endometrial biopsies performed either during the spontaneous, preceding cycle, or during the IVF cycle itself, significantly improve the rate of implantation, clinical pregnancies and live births. These observations suggest that mechanical injury of the endometrium may enhance uterine receptivity by provoking the immune system to generate an inflammatory reaction. In strong support of this idea, we recently found that dendritic cells (DCs), an important cellular component of the innate immune system, play a critical role in successful implantation in a mouse model. In this review, we discuss the hypothesis that the injury-derived inflammation in the biopsy-treated patients generates a focus for uterine DCs accumulation that, in turn, enhances the endometrial expression of essential molecules, which facilitate the interaction between the embryo and the uterine epithelium.
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DOI：
10.1111/j.1600-0897.2004.00156.x
发表时间：
2004-04-01
影响因子：
3.6
作者：
Abrahams, VM;Kim, YM;Mor, G
通讯作者：
Mor, G
影响因子：
64.8
作者：
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DOI：
10.1111/j.1600-0897.2008.00647.x
发表时间：
2008-12-01
影响因子：
3.6
作者：
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通讯作者：
Jeschke, Udo
影响因子：
3.6
作者：
Akbas, GE;Taylor, HS
通讯作者：
Taylor, HS
影响因子：
4
作者：
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Simón, C