"Number needed to read"--how to facilitate clinical trials in MR-angiography.
"Number needed to read"--how to facilitate clinical trials in MR-angiography.
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DOI：
10.1007/s00330-010-1993-2
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发表时间：
2011-05
影响因子：
5.9
通讯作者：
Michaely HJ
中科院分区：
文献类型：
--
作者：
Voth M;Attenberger UI;Luckscheiter A;Haneder S;Henzler T;Schoenberg SO;Schwenke C;Michaely HJ
评价阅片人数对周围MRA统计学结果的影响。本研究纳入了40例外周动脉闭塞性疾病患者作为样本数据集，随机分为两组，n = 20例患者（1组-钆布醇，2组-钆特酸葡胺），在3 T下接受了外周血管的连续平板运动MRA。由5名独立阅片员评价17个血管节段的图像质量（IQ）。统计分析阅片人数对显著性和统计功效的影响。第1组（钆布醇）的图像质量显著高于第2组（钆特胺葡甲胺），诊断IQ分别为97%和78%（p < 0.0001）。对于诊断性/非诊断性IQ评估，1名阅片人达到1/5次（20%），2名阅片人达到4/10次（40%），3名阅片人达到6/10次（60%），4名阅片人达到4/5次（80%），5名阅片人达到1/1次（100%）。当增加读片器的数量时，功率考虑显示出相当大的增益。增加诊断性MRA研究中的阅片者数量可用于实现更高的把握度或减少纳入的受试者数量，同时保持统计学有效性。
To evaluate the effect of the number of readers on the statistical results in peripheral MRA. 40 patients with peripheral arterial occlusive disease were included as a sample dataset in this study, randomly separated into two matched groups with n = 20 patients (group 1—gadobutrol, group 2—gadoterate meglumine) who underwent a continuous table movement MRA of the peripheral vessels at 3 T. Image quality (IQ) of 17 vessel segments was evaluated by 5 independent readers. The effect of the number of readers on significance and statistical power was statistically analyzed. Image quality in group 1 (gadobutrol) ranks significantly higher compared to group 2 (gadoterade meglumine) with a diagnostic IQ in 97% vs. 78% (p < 0.0001). For the diagnostic/non-diagnostic IQ assessment significance was reached with one reader 1/5 times (20%), with two readers in 4/10 (40%), with three readers in 6/10 (60%), with four readers in 4/5 (80%), with five readers in 1/1 (100%). Power considerations showed considerable gain when increasing the number of readers. Increasing the number of readers in a diagnostic MRA-study can be used to achieve a higher power or to decrease the number of subjects included with maintained statistical validity.
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影响因子：
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作者：
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