Acetylcholine signaling system in progression of lung cancers.
Acetylcholine signaling system in progression of lung cancers.
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DOI：
10.1016/j.pharmthera.2018.10.002
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发表时间：
2019-03
影响因子：
13.5
通讯作者：
Dasgupta P
中科院分区：
文献类型：
--
作者：
Friedman JR;Richbart SD;Merritt JC;Brown KC;Nolan NA;Akers AT;Lau JK;Robateau ZR;Miles SL;Dasgupta P
神经递质乙酰胆碱（ACh）作为人类肺癌的自分泌生长因子。几条证据表明，肺癌细胞表达摄取胆碱（胆碱转运蛋白1，胆碱转运蛋白样蛋白）合成ACh（胆碱乙酰转移酶，肉毒碱乙酰转移酶），转运ACh（囊泡乙酰胆碱转运，OCT，OCTN）和降解ACh（乙酰胆碱酯酶，丁酰胆碱酯酶）所需的所有蛋白质。释放的ACh与肺癌细胞上的烟碱（nAChR）和毒蕈碱受体结合，加速其增殖，迁移和侵袭。在胆碱能通路的所有组分中，nAChR信号传导被研究得最深入。这一趋势的原因是由于全基因组数据研究表明，尼古丁受体亚型与肺癌风险有关，香烟烟雾与肺癌风险之间的关系以及电子烟的日益普及被许多人认为是吸烟的“安全”替代品。有少数综述文章综述了其他胆碱能蛋白在肺癌病理生理学中的作用。本文的主要目的是讨论乙酰胆碱信号蛋白在肺癌发生发展中的作用。研究胆碱能网络在肺癌中的作用将为寻找治疗肺癌的新靶点和药物开辟道路。
The neurotransmitter acetylcholine (ACh) acts as an autocrine growth factor for human lung cancer. Several lines of evidence show that lung cancer cells express all of the proteins required for the uptake of choline (choline transporter 1, choline transporter-like proteins) synthesis of ACh (choline acetyltransferase, carnitine acetyltransferase), transport of ACh (vesicular acetylcholine transport, OCTs, OCTNs) and degradation of ACh (acetylcholinesterase, butyrylcholinesterase). The released ACh binds back to nicotinic (nAChRs) and muscarinic receptors on lung cancer cells to accelerate their proliferation, migration and invasion. Out of all components of the cholinergic pathway, the nAChR-signaling has been studied the most intensely. The reason for this trend is due to genome-wide data studies showing that nicotinic receptor subtypes are involved in lung cancer risk, the relationship between cigarette smoke and lung cancer risk as well as the rising popularity of electronic cigarettes considered by many as a “safe” alternative to smoking. There are a small number of review articles which review the contribution of the other cholinergic proteins in the pathophysiology of lung cancer. The primary objective of this review article is to discuss the function of the acetylcholine-signaling proteins in the progression of lung cancer. The investigation of the role of cholinergic network in lung cancer will pave the way to novel molecular targets and drugs in this lethal malignancy.
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影响因子：
5.6
作者：
Arredondo, Juan;Chernyavsky, Alexander I.;Grando, Sergei A.
通讯作者：
Grando, Sergei A.
影响因子：
5.3
作者：
Al-Wadei, Hussein A. N.;Al-Wadei, Mohammed H.;Schuller, Hildegard M.
通讯作者：
Schuller, Hildegard M.
影响因子：
3.5
作者：
Ami, Nozomi;Koga, Kazumi;Ohta, Hisashi
通讯作者：
Ohta, Hisashi
影响因子：
2.7
作者：
BROCHIER, G;ISRAEL, M;LESBATS, B
通讯作者：
LESBATS, B
DOI：
10.1002/cyto.990090504
发表时间：
1988-09-01
期刊：
CYTOMETRY
影响因子：
--
作者：
BROERS, JLV;PAHLPLATZ, MMM;VOOIJS, GP
通讯作者：
VOOIJS, GP