Potential Protective Effects of Equol (Soy Isoflavone Metabolite) on Coronary Heart Diseases-From Molecular Mechanisms to Studies in Humans.
Potential Protective Effects of Equol (Soy Isoflavone Metabolite) on Coronary Heart Diseases-From Molecular Mechanisms to Studies in Humans.
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DOI：
10.3390/nu13113739
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发表时间：
2021-10-23
期刊：
影响因子：
5.9
通讯作者：
Sekikawa A
中科院分区：
文献类型：
--
作者：
Zhang X;Veliky CV;Birru RL;Barinas-Mitchell E;Magnani JW;Sekikawa A
Equol是肠道微生物组的一种大豆异黄酮类代谢物，可能是大豆异黄酮类化合物的关键心脏保护成分。系统评价报告称，大豆异黄酮类化合物对传统的心血管疾病危险因素没有影响，甚至影响很小。然而，马兜铃醇对非传统心血管危险因素的潜在作用机制尚未作系统的综述。我们检索了PubMed到2021年7月，使用了Equol和以下每个标记物：炎症、氧化、内皮功能、血管扩张、动脉粥样硬化、动脉僵硬和冠心病。在确定的231条记录中，有69条符合纳入标准并进行了总结。我们的综述表明，与大豆异黄酮相比，马酚更亲油，更具生物利用度，而且通常更有效。细胞培养、动物和人类研究表明，木醇具有抗氧化、抗炎和血管扩张特性，并可改善动脉僵硬和动脉粥样硬化。这些作用中的许多都是通过雌激素受体β介导的。总体而言，马醇可能比大豆异黄酮有更大的心脏保护益处。对马儿进行临床研究是有必要的，因为马儿可以作为饮食补充剂。
Equol, a soy isoflavone-derived metabolite of the gut microbiome, may be the key cardioprotective component of soy isoflavones. Systematic reviews have reported that soy isoflavones have no to very small effects on traditional cardiovascular disease risk factors. However, the potential mechanistic mode of action of equol on non-traditional cardiovascular risk factors has not been systematically reviewed. We searched the PubMed through to July 2021 by using terms for equol and each of the following markers: inflammation, oxidation, endothelial function, vasodilation, atherosclerosis, arterial stiffness, and coronary heart disease. Of the 231 records identified, 69 articles met the inclusion criteria and were summarized. Our review suggests that equol is more lipophilic, bioavailable, and generally more potent compared to soy isoflavones. Cell culture, animal, and human studies show that equol possesses antioxidative, anti-inflammatory, and vasodilatory properties and improves arterial stiffness and atherosclerosis. Many of these actions are mediated through the estrogen receptor β. Overall, equol may have a greater cardioprotective benefit than soy isoflavones. Clinical studies of equol are warranted because equol is available as a dietary supplement.
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影响因子：
2.5
作者：
Birru RL;Ahuja V;Vishnu A;Evans RW;Miyamoto Y;Miura K;Usui T;Sekikawa A
通讯作者：
Sekikawa A
DOI：
10.1016/j.bbrc.2008.08.027
发表时间：
2008-10-24
影响因子：
3.1
作者：
Chung, Jae-Eun;Kim, Sue Yeon;Kim, Mee-Ran
通讯作者：
Kim, Mee-Ran
影响因子：
2.3
作者：
Nicastro, Holly L.;Mondul, Alison M.;Rohrmann, Sabine;Platz, Elizabeth A.
通讯作者：
Platz, Elizabeth A.
影响因子：
120.7
作者：
Albert, Christine M.;Cook, Nancy R.;Manson, JoAnn E.
通讯作者：
Manson, JoAnn E.
影响因子：
4.2
作者：
Cheng, Charlie;Wang, Xinwen;Chen, Changyi
通讯作者：
Chen, Changyi