Associations between urinary soy isoflavonoids and two inflammatory markers in adults in the United States in 2005-2008.
Associations between urinary soy isoflavonoids and two inflammatory markers in adults in the United States in 2005-2008.
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DOI：
10.1007/s10552-013-0198-9
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发表时间：
2013-06
影响因子：
2.3
通讯作者：
Platz, Elizabeth A.
中科院分区：
文献类型：
--
作者：
Nicastro, Holly L.;Mondul, Alison M.;Rohrmann, Sabine;Platz, Elizabeth A.
本研究的目的是确定2005-2008年美国国家健康与营养调查（NHANES）中美国成人尿中异黄酮（染料木黄酮、大豆苷元和大豆苷元代谢产物O-去甲基安戈林素（O-DMA）和雌马酚）排泄与炎症标志物之间的关联。NHANES是由国家卫生统计中心进行的一项横断面研究，旨在研究生活在美国的人们的健康和营养状况。该分析包括2005-2008年研究期间的1，683名参与者，他们测量了尿肌酐并符合入选标准。采用HPLC-APPI-MS/MS法测定尿肌酐，乳胶散射比浊法测定血清C反应蛋白（CRP）。通过Coulter计数测量白色血细胞（WBC）计数。使用多变量线性回归计算标志物的几何平均值，并使用多变量logistic回归通过尿肌酐的四分位数（nmol/mg肌酐）估计高CRP（≥3 mg/L）和高WBC计数（≥ 7，900/μL）的几率。与最低四分位数相比，染料木黄酮的最高四分位数（OR = 0.62; 95% CI 0.39-0.99）与高CRP的几率显著降低相关。大豆苷元及其代谢产物的总和与血清CRP浓度显著负相关（p趋势= 0.017）。雌马酚与WBC计数呈负相关（p趋势<0.0001）。O-DMA是唯一一种排泄与CRP（p趋势= 0.024）和WBC计数（p趋势<0.0001）降低显著相关的药物。虽然没有出现明确的模式，但某些大豆蛋白的排泄量增加与CRP浓度和WBC计数降低相关，这表明大豆摄入量与炎症之间可能存在负相关性。
The aim of this study was to determine the association between urinary isoflavonoid (genistein, daidzein, and the daidzein metabolites O-desmethylangolensin (O-DMA) and equol) excretion and markers of inflammation in adults in the United States in National Health and Nutrition Examination Survey (NHANES) 2005–2008. The NHANES is a cross-sectional study conducted by the National Center for Health Statistics to study the health and nutritional status of people living in the United States. The analysis included 1,683 participants from study years 2005–2008 for whom urinary isoflavonoids were measured and who met inclusion criteria. Urinary isoflavonoids were measured by HPLC-APPI-MS/MS. Serum C-reactive protein (CRP) was measured by latex-based nephelometry. White blood cell (WBC) count was measured by Coulter counting. Multivariable linear regression was used to calculate the geometric mean values of the markers, and multivariable logistic regression was used to estimate the odds of high CRP (≥3 mg/L) and of high WBC count (≥7,900/μL) by quartile of urinary isoflavonoid (nmol/mg creatinine). The highest quartile of genistein (OR = 0.62; 95 % CI 0.39–0.99) was associated with significantly decreased odds of high CRP compared with the lowest quartile. The sum of daidzein and its metabolites was significantly inversely associated with serum CRP concentration (p-trend = 0.017). Equol was inversely associated with WBC count (p-trend <0.0001). O-DMA was the only isoflavonoid whose excretion was significantly associated with a decrease in both CRP (p-trend = 0.024) and WBC count (p-trend <0.0001). Though no clear pattern emerged, higher excretion of certain soy isoflavonoids was associated with decreased CRP concentration and WBC counts, suggesting a possible inverse association between soy intake and inflammation.
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DOI：
10.1186/1476-9255-6-9
发表时间：
2009-04-07
期刊：
Journal of inflammation (London, England)
影响因子：
--
作者：
Maskarinec G;Steude JS;Franke AA;Cooney RV
通讯作者：
Cooney RV
影响因子：
7.1
作者：
Hall, WL;Vafeiadou, K;Williams, CM
通讯作者：
Williams, CM
DOI：
10.1158/1055-9965.epi-10-0116
发表时间：
2010-07
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Franke AA;Hebshi SM;Pagano I;Kono N;Mack WJ;Hodis HN
通讯作者：
Hodis HN
影响因子：
39.2
作者：
Buckley, David I.;Fu, Rongwei;Helfand, Mark
通讯作者：
Helfand, Mark
影响因子：
9.8
作者：
Arber, Nadir;Spicak, Julius;Levin, Bernard
通讯作者：
Levin, Bernard