CD163 expression was associated with angiogenesis and shortened survival in patients with uniformly treated classical Hodgkin lymphoma.
CD163 expression was associated with angiogenesis and shortened survival in patients with uniformly treated classical Hodgkin lymphoma.
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DOI：
10.1371/journal.pone.0087066
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Huh J
中科院分区：
文献类型：
--
作者：
Koh YW;Park CS;Yoon DH;Suh C;Huh J
最近的研究报道了组织相关巨噬细胞（TAMs）在经典霍奇金淋巴瘤（cHL）中的预后价值。此外，tam还与肿瘤血管生成有关。在这项研究中，我们研究了在统一治疗的cHL病例中，TAMs与血管内皮生长因子（VEGF）表达和血管生成的预后相关性。对116例abvd治疗的cHL患者的诊断组织进行回顾性免疫组织化学分析，检测CD68、CD163和VEGF的表达，以及作为微血管密度（MVD）指标的CD31表达。CD163高表达（≥35%的细胞）与VEGF表达（Pearson 's卡方检验，P = 0.008）和MVD （Spearman相关系数0.310，P<0.001）相关。在单变量分析中，高CD163表达与较差的无事件生存期（EFS, P = 0.005）和总生存期（OS， P<0.001）相关。在多变量分析中，CD163高表达与较差的EFS （P = 0.043）和OS （P = 0.008）密切相关。MVD高的患者OS低于MVD低的患者，但差异无统计学意义（P = 0.071）。虽然CD68的高表达也与较差的EFS相关（P = 0.007），但与VEGF或MVD无关。我们的数据证实CD163表达在cHL中提供了独立的预后信息。CD163与VEGF表达和MVD的相关性提示CD163阳性细胞在cHL肿瘤血管生成中的作用。
Recent studies have reported the prognostic value of tissue-associated magrophages (TAMs) in classical Hodgkin lymphoma (cHL). In addition, TAMs are implicated in the tumor angiogenesis. In this study, we examined the prognostic relevance of TAMs in relation to vascular endothelial growth factor (VEGF) expression and angiogenesis in uniformly treated cases of cHL. Diagnostic tissue from 116 patients with ABVD-treated cHL was evaluated retrospectively by immunohistochemical analysis for CD68, CD163 and VEGF expression and for CD31 expression as a measure of microvessel density (MVD). High CD163 expression (≥35% of cellularity) correlated with VEGF expression (Pearson’s Chi-square test, P = 0.008) and MVD (Spearman correlation coefficient 0.310, P<0.001). High CD163 expression was associated with inferior event-free survival (EFS, P = 0.005) and overall survival (OS, P<0.001) in univariate analysis. In multivariate analysis, high CD163 expression was strongly associated with inferior EFS (P = 0.043) and OS (P = 0.008). Patients with high MVD had a lower OS than those with low MVD, but the difference was not significant (P = 0.071, respectively). While high expression of CD68 was also associated with inferior EFS (P = 0.007), it showed no correlation with VEGF or MVD. Our data confirms that CD163 expression provides independent prognostic information in cHL. The correlation of CD163 with VEGF expression and MVD suggests the role of CD163-positive cells in tumor angiogenesis of cHL.
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影响因子：
7.3
作者：
Doussis-Anagnostopoulou, IA;Talks, KL;Gatter, KC
通讯作者：
Gatter, KC
影响因子：
6
作者：
Gratzinger, Dita;Zhao, Shuchun;Natkunam, Yasodha
通讯作者：
Natkunam, Yasodha
影响因子：
20.3
作者：
Fantin, Alessandro;Vieira, Joaquim M.;Ruhrberg, Christiana
通讯作者：
Ruhrberg, Christiana
影响因子：
2.6
作者：
Jakovic, Ljubomir R.;Mihaljevic, Biljana S.;Bumbasirevic, Vladimir Z.
通讯作者：
Bumbasirevic, Vladimir Z.
DOI：
10.3324/haematol.2010.031542
发表时间：
2011-02-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Kamper, Peter;Bendix, Knud;d'Amore, Francesco
通讯作者：
d'Amore, Francesco