CYP gene family variants as potential protective factors in drug addiction in Han Chinese
CYP gene family variants as potential protective factors in drug addiction in Han Chinese
复制标题
CYP基因家族变异作为汉族吸毒成瘾的潜在保护因素
DOI：
10.1002/jgm.2887
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发表时间：
2016-06
影响因子：
3.5
通讯作者：
Wang Zhenyuan
中科院分区：
文献类型：
--
作者：
Zhang Hongxing;Yang Qi;Zheng Wenkai;Ouyang Yongri;Yang Min;Wang Fengjiao;Jin Tianbo;Zhang Ji;Wang Zhenyuan
背景：越来越多的证据表明遗传因素也会导致药物成瘾。人细胞色素P450由于在不同个体和群体中的药代动力学差异而显示出特别的兴趣，这在很大程度上由相关基因决定。本研究旨在探讨吸毒者与成瘾者关系的多态性。方法：我们对来自三个基因的13个标签单核苷酸多态性（tSNPs）进行了基因分型，包括692例病例和700例对照。Sequenom MassARRAY RS1000（Sequenom，Inc.，San Diego，CA，USA）用于SNP基因分型。使用卡方检验和SNP Stats软件（http：//www.example.com）对tSNP与药物成瘾之间的关联进行统计分析。bioinfo.iconcologia.net结果：CYP 3A 4基因rs 2242480的T/T基因型与隐性模型中的风险降低相关（p = 0.0002）。CYP 1A 2中rs3743484的等位基因频率在成瘾者和对照者之间显示出显著差异（p = 0.046;比值比= 0.80; 95%置信区间= 0.65-1.00）。在遗传模型分析中，CYP 1A 2中rs3743484的次要C等位基因与基于共显性和加性模型分析的药物成瘾风险降低相关（p = 0.027显性模型; p =0.038加性模型）。结论：我们的研究结果表明，在等位基因和基因型水平上，CYP 3A 4和CYP 1A 2的多态性与中国西安汉族个体药物成瘾风险的降低显著相关。然而，这一结果需要在其他研究中得到证实。版权所有© 2016约翰威利父子有限公司.
Background.There is growing evidence that genetic factors also contribute to drug addiction. The human cytochrome P450 has shown special interest because of pharmacokinetic variation in different individuals and populations, which is largely determined by the relevant genes. The present study aimed to investigate the polymorphism of the CYP/addicts relationship...Methods.We genotyped 13 tag single‐nucleotide polymorphisms (tSNPs) from three genes, including 692 cases and 700 controls. Sequenom MassARRAY RS1000 (Sequenom, Inc., San Diego, CA, USA) was used for SNP genotyping. Statistical analysis of the association between tSNPs and drug addiction was performed using the chi‐squared test and SNP Stats software (http://bioinfo.iconcologia.net)...Results.The T/T genotype of rs2242480 in CYP3A4 was associated with decreased risk in the recessive model (p = 0.0002). Allele frequency at rs3743484 in CYP1A2 showed significant differences between addicts and controls (p = 0.046; odds ratio = 0.80; 95% confidence interval = 0.65–1.00). In genetic model analyses, the minor C allele of rs3743484 in CYP1A2 was associated with a reduced risk of drug addiction based on analysis using codominant and additive models (p = 0.027 dominant model; p =0.038 additive model)...Conclusions.Our findings show that at allelic and genotypic level polymorphisms in CYP3A4 and CYP1A2 are significantly associated with a reduced risk of drug addiction in X'ian Han Chinese individuals. However, this result needs to be confirmed in additional studies. Copyright © 2016 John Wiley & Sons, Ltd.
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影响因子：
44.1
作者：
Shi, YY;He, L
通讯作者：
He, L
DOI：
--
发表时间：
1994-07
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
T. Shimada;H. Yamazaki;M. Mimura;Y. Inui;F. Guengerich
通讯作者：
T. Shimada;H. Yamazaki;M. Mimura;Y. Inui;F. Guengerich
影响因子：
3.1
作者：
C. Yun;H. Park;S. J. Kim;H. K. Kim
通讯作者：
C. Yun;H. Park;S. J. Kim;H. K. Kim
影响因子：
6.7
作者：
He, P;Court, MH;von Moltke, LL
通讯作者：
von Moltke, LL
DOI：
10.1097/00008571-199310000-00003
发表时间：
1993-10-01
期刊：
PHARMACOGENETICS
影响因子：
--
作者：
SCHWEIKL, H;TAYLOR, JA;GOLDSTEIN, JA
通讯作者：
GOLDSTEIN, JA