Oxidative Stress and Arterial Dysfunction in Peripheral Artery Disease.
Oxidative Stress and Arterial Dysfunction in Peripheral Artery Disease.
复制标题
外周动脉疾病中的氧化应激和动脉功能障碍。
DOI：
10.3390/antiox7100145
复制
发表时间：
2018-10-19
期刊：
影响因子：
--
通讯作者：
Koutakis P
中科院分区：
文献类型：
--
作者：
Ismaeel A;Brumberg RS;Kirk JS;Papoutsi E;Farmer PJ;Bohannon WT;Smith RS;Eidson JL;Sawicki I;Koutakis P
外周动脉疾病（PAD）是一种动脉粥样硬化性疾病，其特征是下肢动脉狭窄。疾病表现不仅仅是血流减少的结果，还包括内皮功能障碍、动脉僵硬和炎症。越来越多的证据表明，这些因素导致PAD患者的功能障碍和下降。氧化应激在疾病中也起着重要作用，越来越多的数据表明动脉功能障碍和氧化应激之间存在联系。在这篇综述中，我们提出了目前的证据参与内皮功能障碍，动脉僵硬度，炎症的病理生理学PAD。我们还讨论了这些因素和氧化应激之间的联系，重点是烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶2（NOX 2）衍生的活性氧（ROS）和降低一氧化氮（NO）的生物利用度。最后，探讨了NOX2抗氧化剂对改善PAD患者动脉功能和功能状态的潜在治疗作用。
Peripheral artery disease (PAD) is an atherosclerotic disease characterized by a narrowing of the arteries in the lower extremities. Disease manifestations are the result of more than just reduced blood flow, and include endothelial dysfunction, arterial stiffness, and inflammation. Growing evidence suggests that these factors lead to functional impairment and decline in PAD patients. Oxidative stress also plays an important role in the disease, and a growing amount of data suggest a link between arterial dysfunction and oxidative stress. In this review, we present the current evidence for the involvement of endothelial dysfunction, arterial stiffness, and inflammation in the pathophysiology of PAD. We also discuss the links between these factors and oxidative stress, with a focus on nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2)-derived reactive oxygen species (ROS) and decreased nitric oxide (NO) bioavailability. Finally, the potential therapeutic role of NOX2 antioxidants for improving arterial function and functional status in PAD patients is explored.
登录
查看更多内容
影响因子：
2.8
作者：
Folsom, AR;Pankow, JS;Eckfeldt, JH
通讯作者：
Eckfeldt, JH
影响因子：
4.1
作者：
Cauley JA;Kassem AM;Lane NE;Thorson S;Osteoporotic Fractures in Men (MrOS) Study Research Group
通讯作者：
Osteoporotic Fractures in Men (MrOS) Study Research Group
DOI：
10.1016/j.jchromb.2015.01.025
发表时间：
2015-03-15
影响因子：
3
作者：
Chandasana, Hardik;Chhonker, Yashpal S.;Bhatta, Rabi S.
通讯作者：
Bhatta, Rabi S.
影响因子：
4.3
作者：
Brevetti, G;Silvestro, A;Scopacasa, F
通讯作者：
Scopacasa, F
影响因子：
120.1
作者：
Drummond, Grant R.;Selemidis, Stavros;Griendling, Kathy K.;Sobey, Christopher G.
通讯作者：
Sobey, Christopher G.