Prevalent peripheral arterial disease and inflammatory burden.
Prevalent peripheral arterial disease and inflammatory burden.
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DOI：
10.1186/s12877-016-0389-9
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发表时间：
2016-12-09
期刊：
影响因子：
4.1
通讯作者：
Osteoporotic Fractures in Men (MrOS) Study Research Group
中科院分区：
文献类型：
--
作者：
Cauley JA;Kassem AM;Lane NE;Thorson S;Osteoporotic Fractures in Men (MrOS) Study Research Group
强有力的证据表明炎症与动脉粥样硬化性心脏病的发展有关，但对外周动脉疾病（PAD）知之甚少。我们的目的是验证炎症负担的综合指数与PAD相关的假设。对2000年至2002年间招募的903名社区居民的mro队列随机选择的横断面分析。使用血液样本，我们测量了7种细胞因子，并将这些水平与流行的PAD（踝关节-肱指数(ABI) <0.9）单独和作为“炎症负担评分”（最高四分位数中促炎细胞因子数量的复合总和）的一部分联系起来。总体而言，6.75%的男性ABI <0.9。白细胞介素-6多变量（MV）调整后四分位数（Q4）水平最高的男性患PAD的几率更高(优势比(OR) =3.95 (95% CI, 1.4-11.3)，肿瘤坏死因子α OR = 4.44（95%可信区间（CI）， 1.5-12.8)， c反应蛋白OR = 3.63 (95% CI, 1.4-9.4)）。这些细胞因子与PAD的关联程度与10岁的影响相似，OR = 2.41 （95% CI, 1.16-3.7）。除了CRP外，这些显著的影响在额外的吸烟MV调整后仍然存在。炎症负担评分最高（≥3）的男性患PAD的几率增加3.6 (95% CI, 1.5-8.7)， p趋势= 0.03。吸烟调整后，线性趋势有统计学意义（p趋势= 0.10）。炎症负担与普遍的PAD相关，这种关联类似于年龄增长10岁。吸烟的炎症作用有助于炎症和外周动脉疾病之间的潜在联系。
Strong evidence implicates inflammation in the development of atherosclerotic heart disease but less is known about peripheral arterial disease (PAD). Our objective was to test the hypothesis that a composite index of inflammatory burden is associated with PAD. Cross-sectional analysis of a randomly-selected group of 903 community-dwelling men in the MrOS cohort recruited between 2000 and 2002. Using blood samples, we measured seven cytokines and related these levels to prevalent PAD (ankle-brachial index (ABI) <0.9) both individually and as part of an “inflammatory burden score” (a composite sum of the number of pro-inflammatory cytokines in the highest quartile). Overall, 6.75% of men had ABI <0.9. The odds of prevalent PAD were higher in men with the highest quartile (Q4) levels of interleukin-6 multivariable (MV) adjusted (odds ratio (OR) =3.95 (95% CI, 1.4–11.3), tumor necrosis factor alpha OR = 4.44 (95% confidence interval (CI), 1.5–12.8), and C-reactive protein OR = 3.63 (95% CI, 1.4–9.4) compared to men in Q1. The magnitude of the association of these cytokines with PAD was similar to the effect of being 10 years older, OR = 2.41 (95% CI, 1.16–3.7). These significant effects persisted after additional MV adjustment for smoking except for CRP. Men with the highest inflammatory burden score (≥3) had 3.6 (95% CI, 1.5–8.7) increased odds of PAD, p trend = 0.03. After smoking adjustment the linear trend was borderline statistically significant (p trend = 0.10). Inflammatory burden is associated with prevalent PAD, an association similar to aging 10 years. The inflammatory effects of smoking contributes to the underlying association between inflammation and PAD.
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影响因子：
120.7
作者：
Fowkes, F. G. R.;Murray, G. D.;Butcher, I.;Heald, C. L.;Lee, R. J.;Chambless, L. E.;Folsom, A. R.;Hirsch, A. T.;Dramaix, M.;deBacker, G.;Wautrecht, J-C.;Kornitzer, M.;Newman, A. B.;Cushman, M.;Sutton-Tyrrell, K.;Lee, A. J.;Price, J. F.;d'Agostino, R. B.;Murabito, J. M.;Norman, P. E.;Jamrozik, K.;Curb, J. D.;Masaki, K. H.;Rodriquez, B. L.;Dekker, J. M.;Bouter, L. M.;Heine, R. J.;Nijpels, G.;Stehouwer, C. D. A.;Ferrucci, L.;McDermott, M. M.;Stoffers, H. E.;Hooi, J. D.;Knottnerus, J. A.;Ogren, M.;Hedblad, B.;Witteman, J. C.;Breteler, M. M. B.;Hunink, M. G. M.;Hofman, A.;Criqui, M. H.;Langer, R. D.;Fronek, A.;Hiatt, W. R.;Hamman, R.;Resnick, H. E.;Guralnik, J.;McDermott, M. M.
通讯作者：
McDermott, M. M.
影响因子：
24
作者：
McDermott, Mary M.;Guralnik, Jack M.;Criqui, Michael H.
通讯作者：
Criqui, Michael H.
影响因子：
0.2
作者：
Thwaswini, K. O.;Roopakala, M. S.;Kumar, Prasanna K. M.
通讯作者：
Kumar, Prasanna K. M.
影响因子：
2.8
作者：
Wildman, RP;Muntner, P;He, J
通讯作者：
He, J
影响因子：
2.2
作者：
Orwoll, E;Blank, JB;Stone, K
通讯作者：
Stone, K