Effect of recurrent yohimbine on immediate and post-hoc behaviors, stress hormones, and energy homeostatic parameters.
Effect of recurrent yohimbine on immediate and post-hoc behaviors, stress hormones, and energy homeostatic parameters.
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DOI：
10.1016/j.physbeh.2014.02.019
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发表时间：
2014-04-22
影响因子：
2.9
通讯作者：
Sipols AJ
中科院分区：
文献类型：
--
作者：
Figlewicz DP;Hill SR;Jay JL;West CH;Zavosh AS;Sipols AJ
来自实验模型的证据表明，大脑应激和焦虑通路的急性激活会影响由边缘回路介导或调节的后续行为。对这些通路在随后的边缘介导行为中的先前或慢性激活的研究有限。在这项研究中，我们测试了反复给药致焦虑化合物育亨宾（YOH）是否会对注射后大脑激活、应激激素以及蔗糖自我给药和惊吓反应范式的表现产生影响。大鼠在两周内注射了6次2mg /kg的YOH或生理盐水。行为评估证实了YOH方案的持续疗效，并观察到肾上腺皮质酮（CORT）升高。服用YOH或SAL几天后，测量cfo、CORT和促肾上腺皮质激素（ACTH）以及行为表现。yoh后海马cFos升高；腹侧被盖区/区插入；杏仁核的中央核和内侧核。这种激活与YOH在中枢神经系统中激活恐惧和焦虑回路的持续效应是一致的。惊悸试验后，yoh大鼠的CORT升高，但ACTH未升高。自我给药和惊吓试验表明，yoh后大鼠非特异性活性增加；自我给糖或惊吓反应本身没有增加。我们的研究结果表明，反复服用YOH可能被证明是模拟反复出现的压力/焦虑的有用和可靠的模型，并且对范式的增强，如更高或更频繁的YOH剂量可以产生更强或更广泛的行为影响。
Evidence from experimental models has suggested that acute activation of brain stress and anxiety pathways impacts subsequent behaviors that are mediated or modulated by limbic circuitry. There have been limited investigations of prior or chronic activation of these pathways on subsequent limbic-mediated behaviors. In this study, we tested whether recurrent administration of the anxiogenic compound yohimbine (YOH) could have post-injection effects on brain activation, stress hormones, and performance in sucrose self-administration and startle response paradigms. Rats received six injections across two weeks of either 2 mg/kg YOH or saline. Behavioral evaluation confirmed the continued efficacy of the YOH regimen, and increased adrenal corticosterone (CORT) was observed. Several days following YOH or SAL administration, cFos, CORT and adrenocorticotropin hormone (ACTH), and behavioral performance were measured. cFos was elevated post-YOH in the hippocampus; ventral tegmental area/zona inserta; and central and medial nuclei of the amygdala. This activation is consistent with a sustained effect of YOH to activate fear and anxiety circuitry in the CNS. CORT but not ACTH was elevated in the YOH-rats following startle testing. Self-administration and startle tests suggested an increase of non-specific activity in the post-YOH rats; there was no increase in sucrose self-administration or startle response per se. Our findings suggest that recurrent YOH administration may prove a useful and reliable model for simulating recurrent stress/anxiety, and that enhancements to the paradigm such as higher or more frequent dosing of YOH could yield stronger or more extensive behavioral effects.
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DOI：
10.3109/10253890.2010.531331
发表时间：
2011-03
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
--
作者：
Christiansen AM;Herman JP;Ulrich-Lai YM
通讯作者：
Ulrich-Lai YM
DOI：
10.1152/ajpregu.00655.2010
发表时间：
2011-04-01
影响因子：
2.8
作者：
Figlewicz, Dianne P.;Bennett-Jay, Jennifer L.;Zavosh, Aryana
通讯作者：
Zavosh, Aryana
影响因子：
10.6
作者：
Smith, Rachel J.;Aston-Jones, Gary
通讯作者：
Aston-Jones, Gary
粮食寻求食物的复发的神经药理学：方法论，主要发现和与寻求药物的复发的比较。
影响因子：
6.7
作者：
Nair SG;Adams-Deutsch T;Epstein DH;Shaham Y
通讯作者：
Shaham Y
DOI：
10.1196/annals.1364.056
发表时间：
2006-01-01
期刊：
PSYCHOBIOLOGY OF POSTTRAUMATIC STRESS DISORDER: A DECADE OF PROGRESS
影响因子：
--
作者：
Debiec, Jacek;LeDoux, Joseph E.
通讯作者：
LeDoux, Joseph E.