Microphysiological Systems: Design, Fabrication, and Applications.
Microphysiological Systems: Design, Fabrication, and Applications.
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DOI：
10.1021/acsbiomaterials.9b01667
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发表时间：
2020-06-08
影响因子：
5.8
通讯作者：
Yang Y
中科院分区：
文献类型：
--
作者：
Wang K;Man K;Liu J;Liu Y;Chen Q;Zhou Y;Yang Y
微生理系统，包括有机化合物、3D打印组织结构和芯片上器官(器官芯片)，在体外模型中具有生理相关性，在过去的几十年中经历了爆炸性的增长。与传统的基于组织培养塑料的体外模型或动物模型不同，微生理系统概括了人体器官的关键微环境特征，并模拟了它们的主要功能。微生理系统的出现归功于不断发展的生物材料、微/纳米技术和干细胞生物学，它们使得在生理条件下能够精确地控制基质的性质以及细胞、组织和器官之间的相互作用。因此，已经开发了微生理系统来模拟从微血管系统、眼睛到肺和许多其他器官的广泛范围，以了解人类器官的发育和疾病病理，并促进药物发现。多器官芯片系统也是通过将多个相关的器官芯片集成到一个单一平台中而开发出来的，这使得能够以系统的方法研究和使用器官功能。在这里，我们首先讨论微生理系统的设计原则，重点是器官的解剖学和生理学，然后综述微生理系统常用的制造技术和生物材料。随后，我们讨论了微生理系统的最新发展，并提出了我们对发展微生理系统用于临床前研究和人类疾病药物发现的展望。
Microphysiological systems, including organoids, 3-D printed tissue constructs and organ-on-a-chips (organ chips), are physiologically relevant in vitro models and have experienced explosive growth in the past decades. Different from conventional, tissue culture plastic-based in vitro models or animal models, microphysiological systems recapitulate key microenvironmental characteristics of human organs and mimic their primary functions. The advent of microphysiological systems is attributed to evolving biomaterials, micro-/nanotechnologies and stem cell biology, which enable the precise control over the matrix properties and the interactions between cells, tissues and organs in physiological conditions. As such, microphysiological systems have been developed to model a broad spectrum of organs from microvasculature, eye, to lung and many others to understand human organ development and disease pathology and facilitate drug discovery. Multiorgans-on-a-chip systems have also been developed by integrating multiple associated organ chips in a single platform, which allows to study and employ the organ function in a systematic approach. Here we first discuss the design principles of microphysiological systems with a focus on the anatomy and physiology of organs, and then review the commonly used fabrication techniques and biomaterials for microphysiological systems. Subsequently, we discuss the recent development of microphysiological systems, and provide our perspectives on advancing microphysiological systems for preclinical investigation and drug discovery of human disease.
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影响因子：
3.1
作者：
Birukova, Anna A.;Tian, Xinyong;Cokic, Ivan;Beckham, Yvonne;Gardel, Margaret L.;Birukov, Konstantin G.
通讯作者：
Birukov, Konstantin G.
影响因子：
4.7
作者：
Boland, Thomas;Xu, Tao;Cui, Xiaofeng
通讯作者：
Cui, Xiaofeng
影响因子：
3.4
作者：
Ahearne, Mark;Wilson, Samantha L.;Yang, Ying
通讯作者：
Yang, Ying
影响因子：
6.1
作者：
Agarwal A;Goss JA;Cho A;McCain ML;Parker KK
通讯作者：
Parker KK
影响因子：
64.8
作者：
Birey F;Andersen J;Makinson CD;Islam S;Wei W;Huber N;Fan HC;Metzler KRC;Panagiotakos G;Thom N;O'Rourke NA;Steinmetz LM;Bernstein JA;Hallmayer J;Huguenard JR;Paşca SP
通讯作者：
Paşca SP