Early Stage Longitudinal Subcortical Volumetric Changes following Mild Traumatic Brain Injury.
Early Stage Longitudinal Subcortical Volumetric Changes following Mild Traumatic Brain Injury.
复制标题
DOI：
10.1080/02699052.2021.1906445
复制
发表时间：
2021-05-12
期刊：
影响因子：
1.9
通讯作者：
Gullapalli RP
中科院分区：
文献类型：
--
作者：
Zhuo J;Jiang L;Sours Rhodes C;Roys S;Shanmuganathan K;Chen H;Prince JL;Badjatia N;Gullapalli RP
研究mTBI后急性至6个月深部灰质区域的早期脑体积变化及其与患者6个月结局的相关性。五十六例mTBI患者在急性（<10天）和损伤后约1个月和6个月接受MRI和行为评估。区域体积的变化进行了研究，在关键的灰质区域：丘脑，海马，壳核，尾状核，苍白球，杏仁核，并与34名健康对照组的体积进行了比较。在mTBI患者中，我们进一步评估了纵向区域体积变化与6个月时患者结局指标（包括脑震荡后症状、认知表现和总体生活满意度）之间的相关性。在mTBI患者中，在1个月时观察到丘脑和海马体积减少。这种体积减少持续在丘脑，直到6个月。丘脑体积的变化也与6个月时患者的多种症状和功能结局指标相关。我们的研究结果表明，丘脑可能会受到不同的影响与mTBI患者，导致结构和功能缺陷与随后的脑震荡后遗症，并可能作为一个生物标志物评估新的治疗干预措施的疗效。
To investigate early brain volumetric changes from acute to 6 months following mTBI in deep gray matter regions and their association with patient 6-month outcome. Fifty-six patients with mTBI underwent MRI and behavioural evaluation at acute (<10 days) and approximately 1 and 6 months post-injury. Regional volume changes were investigated in key gray matter regions: thalamus, hippocampus, putamen, caudate, pallidum, and amygdala, and compared with volumes from 34 healthy control subjects. In patients with mTBI, we further assessed associations between longitudinal regional volume changes with patient outcome measures at 6 months including post-concussive symptoms, cognitive performance, and overall satisfaction with life). Reduction in thalamic and hippocampal volumes was observed at one month among patients with mTBI. Such volume reduction persisted in the thalamus until 6 months. Changes in thalamic volumes also correlated with multiple symptom and functional outcome measures in patients at 6 months. Our results indicate that the thalamus may be differentially affected among patients with mTBI, resulting in both structural and functional deficits with subsequent post-concussive sequelae and may serve as a biomarker for assessment of efficacy of novel therapeutic interventions.
登录
查看更多内容
轻度创伤性脑损伤后，丘脑在丘脑的高度连接性。
影响因子：
3.2
作者：
Sours C;George EO;Zhuo J;Roys S;Gullapalli RP
通讯作者：
Gullapalli RP
影响因子：
5.7
作者：
Reuter, Martin;Schmansky, Nicholas J.;Rosas, H. Diana;Fischl, Bruce
通讯作者：
Fischl, Bruce
影响因子：
9.9
作者：
Levine, B.;Kovacevic, N.;Black, S. E.
通讯作者：
Black, S. E.
影响因子：
5.7
作者：
Morra JH;Tu Z;Apostolova LG;Green AE;Avedissian C;Madsen SK;Parikshak N;Toga AW;Jack CR Jr;Schuff N;Weiner MW;Thompson PM;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
2.9
作者：
Bigler ED
通讯作者：
Bigler ED