Traumatic brain injury, neuroimaging, and neurodegeneration.
Traumatic brain injury, neuroimaging, and neurodegeneration.
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DOI：
10.3389/fnhum.2013.00395
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发表时间：
2013
影响因子：
2.9
通讯作者：
Bigler ED
中科院分区：
文献类型：
--
作者：
Bigler ED
根据严重程度，创伤性脑损伤（TBI）诱导即时的神经病理学效应，其在最轻微的形式下可能是短暂的，但随着严重程度的增加导致神经损伤和变性。神经变性的第一阶段可以通过损伤引起的原发性急性和继发性神经病理学效应来解释;然而，神经影像学研究表明，即使在慢性阶段，也会发生长期的病理学变化。本文综述了如何在TBI中使用神经影像学来理解（1）与理解TBI影响相关的脑发育中发生的动态变化以及这些变化与脑损伤时的发育阶段的关系，（2）TBI如何干扰年龄典型的脑发育以及此后衰老的影响，以及（3）TBI如何导致更大的额颞叶边缘损伤，导致脑萎缩，并且对白色物质神经连接的破坏性更大。TBI的神经影像学定量显示了脑损伤随着时间的推移而产生的退行性影响。TBI与衰老的不利协同影响可能使脑损伤个体在脑损伤存活很长时间后易于发展神经精神和神经退行性疾病。
Depending on severity, traumatic brain injury (TBI) induces immediate neuropathological effects that in the mildest form may be transient but as severity increases results in neural damage and degeneration. The first phase of neural degeneration is explainable by the primary acute and secondary neuropathological effects initiated by the injury; however, neuroimaging studies demonstrate a prolonged period of pathological changes that progressively occur even during the chronic phase. This review examines how neuroimaging may be used in TBI to understand (1) the dynamic changes that occur in brain development relevant to understanding the effects of TBI and how these relate to developmental stage when the brain is injured, (2) how TBI interferes with age-typical brain development and the effects of aging thereafter, and (3) how TBI results in greater frontotemporolimbic damage, results in cerebral atrophy, and is more disruptive to white matter neural connectivity. Neuroimaging quantification in TBI demonstrates degenerative effects from brain injury over time. An adverse synergistic influence of TBI with aging may predispose the brain injured individual for the development of neuropsychiatric and neurodegenerative disorders long after surviving the brain injury.
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影响因子：
1.9
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