Exploring Eimeria Genomes to Understand Population Biology: Recent Progress and Future Opportunities.
Exploring Eimeria Genomes to Understand Population Biology: Recent Progress and Future Opportunities.
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DOI：
10.3390/genes11091103
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发表时间：
2020-09-21
期刊：
影响因子：
3.5
通讯作者：
Jenkins MC
中科院分区：
文献类型：
--
作者：
Blake DP;Worthing K;Jenkins MC
艾美耳球虫属（Eimeria）是一种寄生于顶复门（Apicomplexa）的原虫，可引起各种养殖动物的肠道球虫病。球虫病通常被认为是家禽中最重要的;部分原因是世界上每年生产的大量鸡，它们的世代时间短，以及与其生产相关的利润率很低。艾美耳球虫的控制长期以来一直以常规的化学预防为主，但在少数生产部门已被活寄生虫疫苗接种补充或取代。然而，公众和立法机构对减少食品生产中药物使用的需求正在推动巨大的变化，用艾美球虫属物种（在某些情况下是菌株特异性的）疫苗取代了对相对不加选择的抗球虫药物的依赖。不幸的是，暴露于抗球虫药物或疫苗对艾美耳球虫种群结构和基因组进化的有害选择的后果尚不清楚。2014年发表了感染鸡的所有七种艾美球虫的基因组序列组装，刺激了这些经济上重要的寄生虫的第一次群体遗传学研究。在这里，我们回顾了目前的艾美耳球虫基因组的知识，并强调了新的，遗传上神秘的艾美耳球虫操作分类单位（OTUs）在鸡群中流通的发现所带来的挑战。随着测序技术的发展，对艾美耳球虫基因组的了解将得到改善，这对艾美耳球虫生物学，多样性和控制机会的研究具有显着的实用性。
Eimeria, protozoan parasites from the phylum Apicomplexa, can cause the enteric disease coccidiosis in all farmed animals. Coccidiosis is commonly considered to be most significant in poultry; due in part to the vast number of chickens produced in the World each year, their short generation time, and the narrow profit margins associated with their production. Control of Eimeria has long been dominated by routine chemoprophylaxis, but has been supplemented or replaced by live parasite vaccination in a minority of production sectors. However, public and legislative demands for reduced drug use in food production is now driving dramatic change, replacing reliance on relatively indiscriminate anticoccidial drugs with vaccines that are Eimeria species-, and in some examples, strain-specific. Unfortunately, the consequences of deleterious selection on Eimeria population structure and genome evolution incurred by exposure to anticoccidial drugs or vaccines are unclear. Genome sequence assemblies were published in 2014 for all seven Eimeria species that infect chickens, stimulating the first population genetics studies for these economically important parasites. Here, we review current knowledge of eimerian genomes and highlight challenges posed by the discovery of new, genetically cryptic Eimeria operational taxonomic units (OTUs) circulating in chicken populations. As sequencing technologies evolve understanding of eimerian genomes will improve, with notable utility for studies of Eimeria biology, diversity and opportunities for control.
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DOI：
10.1186/s12711-018-0433-7
发表时间：
2018-11-21
期刊：
Genetics, selection, evolution : GSE
影响因子：
--
作者：
Boulton K;Nolan MJ;Wu Z;Psifidi A;Riggio V;Harman K;Bishop SC;Kaiser P;Abrahamsen MS;Hawken R;Watson KA;Tomley FM;Blake DP;Hume DA
通讯作者：
Hume DA
DOI：
10.1016/j.ijpddr.2014.10.002
发表时间：
2014-12
影响因子：
4
作者：
Chapman, H. David;Jeffers, Thomas K.
通讯作者：
Jeffers, Thomas K.
影响因子：
6.7
作者：
Blake DP;Billington KJ;Copestake SL;Oakes RD;Quail MA;Wan KL;Shirley MW;Smith AL
通讯作者：
Smith AL
影响因子：
4
作者：
Clark EL;Macdonald SE;Thenmozhi V;Kundu K;Garg R;Kumar S;Ayoade S;Fornace KM;Jatau ID;Moftah A;Nolan MJ;Sudhakar NR;Adebambo AO;Lawal IA;Álvarez Zapata R;Awuni JA;Chapman HD;Karimuribo E;Mugasa CM;Namangala B;Rushton J;Suo X;Thangaraj K;Srinivasa Rao AS;Tewari AK;Banerjee PS;Dhinakar Raj G;Raman M;Tomley FM;Blake DP
通讯作者：
Blake DP
DOI：
10.1073/pnas.1506468112
发表时间：
2015-09-22
影响因子：
11.1
作者：
Blake, Damer P.;Clark, Emily L.;Tomley, Fiona M.
通讯作者：
Tomley, Fiona M.