Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production.
Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production.
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DOI：
10.1016/j.ijpddr.2014.10.002
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发表时间：
2014-12
影响因子：
4
通讯作者：
Jeffers, Thomas K.
中科院分区：
文献类型：
--
作者：
Chapman, H. David;Jeffers, Thomas K.
所有用于控制鸡球虫病的药物都产生了抗药性。一些疫苗含有对药物敏感的艾美耳球虫菌株。这些菌株可能会取代商业禽舍中的抗药性菌株。介绍了一种包括化疗和疫苗接种的生产周期。这样的年度周期可能会恢复对抗球虫药物的敏感性。凡是在集约化条件下饲养牲畜，并使用药物抗击寄生虫感染的地方，耐药性就是一个问题。对于用于预防家禽艾美耳球虫属原生动物引起的球虫病的抗球虫剂尤其如此。所有十几种被批准用于鸡的药物都有抗药性记录，目前使用的药物存在不同程度的抗药性。一种可能的解决方案可能是在饲养家禽的房屋中引入对药物敏感的寄生虫，以便它们可以取代这种抗药性生物。这可以通过使用含有艾美耳球虫菌株的活疫苗来实现，这些菌株是在大多数抗球虫化合物引入之前分离出来的。这类菌株天生对药物敏感。实现这一目标的实际建议涉及在同一鸡舍饲养的连续鸡群中交替接种疫苗和药物(称为轮换计划)。提出了一种每年一次的肉鸡生产周期，包括化疗和疫苗接种。在兽医寄生虫学中，证明有可能恢复对用于控制广泛传播的寄生虫的药物的敏感性的例子很少。有必要进行进一步研究，以确定这是否能够实现对家禽艾美耳球虫感染的可持续和长期控制。
Resistance has developed to all those drugs used to control coccidiosis in chickens. Some vaccines contain strains of Eimeria that are sensitive to drugs. Such strains may replace drug resistant strains in commercial poultry houses. A production cycle involving chemotherapy followed by vaccination is presented. Such a yearly cycle may restore sensitivity to anticoccidial drugs. Drug resistance is a problem wherever livestock are raised under intensive conditions and drugs are used to combat parasitic infections. This is particularly true for the anticoccidial agents used for the prevention of coccidiosis caused by protozoa of the apicomplexan genus Eimeria in poultry. Resistance has been documented for all the dozen or so drugs approved for use in chickens and varying levels of resistance is present for those currently employed. A possible solution may be the introduction of drug-sensitive parasites into the houses where poultry are raised so that they may replace such drug-resistant organisms. This can be achieved by utilizing live vaccines that contain strains of Eimeria that were isolated before most anticoccidial compounds were introduced. Such strains are inherently drug-sensitive. Practical proposals to achieve this objective involve the alternation of vaccination with medication (known as rotation programs) in successive flocks reared in the same poultry house. A proposal for a yearly broiler production cycle involving chemotherapy and vaccination is presented. There are few, if any, examples in veterinary parasitology where it has proved possible to restore sensitivity to drugs used to control a widespread parasite. Further research is necessary to ascertain whether this can result in sustainable and long-term control of Eimeria infections in poultry.
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影响因子：
4
作者：
Chapman, HD;Cherry, TE;Williams, RB
通讯作者：
Williams, RB
影响因子：
2.1
作者：
CANNING, EU;MORGAN, K
通讯作者：
MORGAN, K
影响因子：
1.4
作者：
Jenkins, M.;Klopp, S.;Fetterer, R.
通讯作者：
Fetterer, R.
影响因子：
1.4
作者：
JEFFERS, TK
通讯作者：
JEFFERS, TK
影响因子：
1.3
作者：
JEFFERS, TK
通讯作者：
JEFFERS, TK