Reframing Histological Risk Assessment of Oral Squamous Cell Carcinoma in the Era of UICC 8th Edition TNM Staging.
Reframing Histological Risk Assessment of Oral Squamous Cell Carcinoma in the Era of UICC 8th Edition TNM Staging.
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在UICC第8版TNM分期时代重新构建口腔鳞状细胞癌的组织学风险评估。
DOI：
10.1007/s12105-020-01201-8
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发表时间：
2021-03
影响因子：
2.1
通讯作者：
Conn B
中科院分区：
文献类型：
--
作者：
Rahman N;MacNeill M;Wallace W;Conn B
为了评估应用Brandwein-Gensler最初提出的风险模型是否会影响接受口腔鳞状细胞癌（OSCC）治疗的患者的生存和疾病进展。来自134例T1和T2 OSCC切除术（第7版）的肿瘤由3名组织病理学家根据最坏侵袭模式（WPOI）、淋巴细胞宿主反应（LHR）和神经周围侵袭（PNI）独立评分，并根据风险评分进行分类。局部复发、局部区域复发、疾病进展和总生存期为研究终点。还评估了病理评分的观察者间可变性。72例（54%）患者为低或中危，62例（46%）患者为“高危”。观察者间的一致意见与共识分数（k范围= 0.45-0.82）有中等到强烈的一致。远处转移与“高风险”肿瘤之间有统计学意义。在第8版TNM分期中，30个肿瘤被抢到了T3，其中83%的肿瘤具有高风险评分。与tnm7 T期相比，总风险评分和TNM8 T期与总生存率有显著相关性。“高风险”肿瘤与远处转移显著相关，这可能是由于WPOI和PNI等侵袭性特征的可能性更大。随着T期的增加，原发性肿瘤更有可能表现出高危特征。没有一个被归类为“低风险”的患者死亡，这可能表明这些肿瘤代表了一种罕见的OSCC变体，预后良好。
To assess whether application of the risk model originally proposed by Brandwein-Gensler, influences survival and disease progression in patients treated for oral squamous cell carcinoma (OSCCs) Tumours from 134 T1 and T2 OSCC resections (7th edition) were scored independently by 3 histopathologists according to worst pattern of invasion (WPOI), lymphocytic host response (LHR) and perineural invasion (PNI) and categorised according to risk score. Local recurrence, locoregional recurrence, disease progression and overall survival were study endpoints. Interobserver variability of pathologist scoring was also assessed. Seventy-two patients (54%) were classified with low or intermediate risk and 62 (46%) patients were ‘high risk’. The inter-observer agreement was in moderate to strong agreement with the consensus scores (k range = 0.45–0.82). There was statistical significance between distant metastasis and ‘high risk’ tumours. Thirty tumours were upstaged to T3 in the 8th edition TNM staging, of which 83% had high risk scores. Overall risk score and TNM8 T stage has significant correlation with overall survival in comparison to the TNM 7 T stage. ‘High risk’ tumours were significantly associated with distant metastasis possibly due to the greater likelihood of aggressive features such as WPOI and PNI. Primary tumours are more likely to express high risk features with increasing T stage. None of the patients classified as ‘low risk’ died perhaps suggesting these tumours represent a rare variant of OSCC with excellent prognosis.
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影响因子：
6.4
作者：
Boxberg, Melanie;Jesinghaus, Moritz;Weichert, Wilko
通讯作者：
Weichert, Wilko
DOI：
10.1016/j.ijom.2014.01.014
发表时间：
2014-07-01
影响因子：
2.4
作者：
Rodrigues, P. C.;Miguel, M. C. C.;Coletta, R. D.
通讯作者：
Coletta, R. D.
DOI：
10.1007/s00432-009-0749-3
发表时间：
2010-07-01
影响因子：
3.6
作者：
Vered, Marilena;Dayan, Dan;Taicher, Shlomo
通讯作者：
Taicher, Shlomo
DOI：
10.1001/jama.1920.02620100016007
发表时间：
1920-01-01
影响因子：
--
作者：
Broders, AC
通讯作者：
Broders, AC
影响因子：
3.4
作者：
Boxberg, Melanie;Bollwein, Christine;Weichert, Wilko
通讯作者：
Weichert, Wilko