Sodium-lithium countertransport genotype and the probability of hypertension in adults.
Sodium-lithium countertransport genotype and the probability of hypertension in adults.
复制标题
钠-锂逆向转运基因型和成人高血压的概率。
DOI：
10.1161/01.hyp.22.4.560
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Sing,CF
中科院分区：
文献类型：
--
作者：
Rebbeck,TR;Turner,ST;Sing,CF
本研究的目的是确定是否有一个生物统计学推断的红细胞钠-锂反向转运的影响大的单基因的信息是有用的，在预测高血压的概率。我们使用多变量逻辑回归对来自明尼苏达州罗切斯特的382名无关成年女性和347名无关成年男性的样本中患有高血压的概率与预测特征之间的关系进行建模。首先，我们确定了一组人口统计学、生物化学和生理学预测因子。其次，我们分析了是否有高血压的概率和确定的预测性状之间的关系是异质性的生物统计学推断的单位点基因型与钠-锂反向转运水平的影响很大。第三，如果没有异质性，我们评估了钠-锂反向转运基因型是否在考虑其他预测因素后对预测高血压的概率做出了额外的贡献。在女性中，高血压概率的预测因子是年龄、血浆载脂蛋白CIII、体重指数以及年龄和体重指数的交互作用项。高血压的概率和已确定的预测因子之间的关系是不异质性的钠-锂反向转运基因型，基因型没有贡献的高血压的概率的预测后，已确定的预测因素被认为是。在男性中，高血压概率的预测因子是年龄、血浆高密度脂蛋白胆固醇、载脂蛋白AI和CII水平、钠-锂反向转运水平和钠-锂反向转运基因型。高血压患病概率与钠-锂反向转运水平和年龄的关系在生物统计学推断的钠-锂反向转运基因型之间存在异质性。（250字处删节）
The objective of the present study was to determine whether information about a biometrically inferred single gene with large effects on erythrocyte sodium-lithium countertransport is useful in predicting the probability of having hypertension. We used multivariate logistic regression to model the relationship between the probability of having hypertension and predictor traits in a sample of 382 unrelated adult women and 347 unrelated adult men from Rochester, Minn. First, we identified a set of demographic, biochemical, and physiological predictors. Second, we analyzed whether the relationship between the probability of having hypertension and the identified predictor traits was heterogeneous between the biometrically inferred single locus genotypes with large effects on sodium-lithium countertransport level. Third, if there was no heterogeneity, we assessed whether sodium-lithium countertransport genotypes made an additional contribution to predicting the probability of having hypertension after other predictors were considered. In women, the predictors of the probability of having hypertension were age, plasma apolipoprotein CIII, body mass index, and an interaction term involving age and body mass index. The relationship between the probability of having hypertension and the identified predictors was not heterogeneous between sodium-lithium countertransport genotypes, and genotype did not contribute to the prediction of the probability of having hypertension after the identified predictors were considered. In men, predictors of the probability of having hypertension were age, plasma levels of high-density lipoprotein cholesterol, apolipoproteins AI and CII, sodium-lithium countertransport level, and sodium-lithium countertransport genotype. The relationship between the probability of having hypertension and sodium-lithium countertransport level and age were heterogeneous between biometrically inferred sodium-lithium countertransport genotypes.(ABSTRACT TRUNCATED AT 250 WORDS)
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影响因子：
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作者：
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影响因子：
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发表时间：
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作者：
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通讯作者：
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