Mechanisms of aphasia recovery after stroke and the role of noninvasive brain stimulation.
Mechanisms of aphasia recovery after stroke and the role of noninvasive brain stimulation.
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DOI：
10.1016/j.bandl.2011.02.005
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发表时间：
2011-07
影响因子：
2.5
通讯作者：
Coslett, Branch
中科院分区：
文献类型：
--
作者：
Hamilton, Roy H.;Chrysikou, Eyangelia G.;Coslett, Branch
关键词：
单侧中风最常见的症状之一是失语症，即语言功能的损伤或丧失。在过去的几年里，行为和神经影像学研究表明，康复干预可以促进失语症患者的神经可塑性变化，这可能与语言功能的改善有关。左半球中风后，失语症患者的语言功能重组被认为涉及受损左半球和病变周围部位之间的半球内相互作用以及受损左半球语言区和右半球同源区之间的胼胝体半球间相互作用。越来越多的证据表明，这种重组来自于使用经颅磁刺激（TMS）和经颅直流电刺激（tDCS）的研究，这两种安全且无创的程序可以在临床上应用于中风后语言恢复期间调节皮质兴奋性。我们讨论了一个层次模型的可塑性变化的语言表征，发生在设置优势半球中风和失语症。我们进一步认为，经颅磁刺激和tDCS是潜在的有前途的工具，提高语言的功能恢复和进一步阐明失语症患者的可塑性机制。
One of the most frequent symptoms of unilateral stroke is aphasia, the impairment or loss of language functions. Over the past few years, behavioral and neuroimaging studies have shown that rehabilitation interventions can promote neuroplastic changes in aphasic patients that may be associated with the improvement of language functions. Following left-hemisphere strokes, the functional reorganization of language in aphasic patients has been proposed to involve both intrahemispheric interactions between damaged left-hemisphere and perilesional sites and transcallosal interhemispheric interactions between the lesioned left-hemisphere language areas and homotopic regions in the right hemisphere. A growing body of evidence for such reorganization comes from studies using transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), two safe and noninvasive procedures that can be applied clinically to modulate cortical excitability during poststroke language recovery. We discuss a hierarchical model for the plastic changes in language representation that occur in the setting of dominant hemisphere stroke and aphasia. We further argue that TMS and tDCS are potentially promising tools for enhancing functional recovery of language and for further elucidating mechanisms of plasticity in patients with aphasia.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1017/s1355617706061017
发表时间：
2006-11-01
影响因子：
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作者：
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通讯作者：
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