Commensal Fungi in Health and Disease.

Commensal Fungi in Health and Disease.
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健康和疾病的共生真菌。

DOI:
10.1016/j.chom.2017.07.002
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发表时间:
2017-08-09
影响因子:
30.3
通讯作者:
Underhill DM
Underhill DM
中科院分区:
医学1区
文献类型:
--
作者:
Limon JJ;Skalski JH;Underhill DM

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真菌越来越多地被认为是几乎所有粘膜表面上发现的微生物组的常见成员,并且人们对了解这些生物体如何有助于健康和疾病的兴趣越来越大。在这篇综述中,我们调查了我们对真菌微生物群或“真菌生物群”的理解的最新进展,包括表征它所面临的挑战,这些生物体的发现,它们的多样性,以及它们如何与宿主免疫相互作用。越来越多的证据表明,与细菌微生物群一样,真菌微生物群在疾病状态下经常发生变化,越来越多的研究旨在探索这种真菌生态失调对健康和疾病的功能后果。
Fungi are increasingly being recognized as common members of the microbiomes found on nearly all mucosal surfaces, and interest is growing in understanding how these organisms may contribute to health and disease. In this review, we investigate recent developments in our understanding of the fungal microbiota or “mycobiota” including challenges faced in characterizing it, where these organisms are found, their diversity, and how they interact with host immunity. Growing evidence indicates that like the bacterial microbiota, the fungal microbiota is often altered in disease states, and increasingly studies are being designed to probe the functional consequences of such fungal dysbiosis on health and disease.
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