The human gut microbiome and body metabolism: implications for obesity and diabetes.

The human gut microbiome and body metabolism: implications for obesity and diabetes.
复制标题

DOI:
10.1373/clinchem.2012.187617
复制
发表时间:
2013-04
期刊:
影响因子:
9.3
通讯作者:
Versalovic J
Versalovic J
中科院分区:
医学1区
文献类型:
--
作者:
Devaraj S;Hemarajata P;Versalovic J

文献摘要

参考文献

被引文献

相似文献

肥胖、代谢综合征和2型糖尿病是主要的公共卫生挑战。最近,人们对肠道微生物群作为这三种疾病患病率增加的潜在新贡献者的可能作用的兴趣激增。微生物DNA测序技术的最新进展导致全基因组测序技术广泛应用于复杂生态系统(如人类肠道)的宏基因组DNA分析。目前的证据表明,肠道微生物群影响营养获取,能量收获,和无数宿主代谢途径。人类微生物组计划和人类宏基因组学研究的进展将引导人们更好地了解肠道微生物组在代谢紊乱(如肥胖、代谢综合征和糖尿病)中的重要性和作用。
Obesity, metabolic syndrome, and type 2 diabetes are major public health challenges. Recently, interest has surged regarding the possible role of the intestinal microbiota as potential novel contributors to the increased prevalence of these 3 disorders. Recent advances in microbial DNA sequencing technologies have resulted in the widespread application of whole-genome sequencing technologies for metagenomic DNA analysis of complex ecosystems such as the human gut. Current evidence suggests that the gut microbiota affect nutrient acquisition, energy harvest, and a myriad of host metabolic pathways. Advances in the Human Microbiome Project and human metagenomics research will lead the way toward a greater understanding of the importance and role of the gut microbiome in metabolic disorders such as obesity, metabolic syndrome, and diabetes.
DOI: 10.1016/j.pcl.2011.07.005
发表时间: 2011-10-01
影响因子: 2.6
作者:
D'Adamo, Ebe;Santoro, Nicola;Caprio, Sonia
通讯作者: Caprio, Sonia
DOI: 10.2337/dc08-1296
发表时间: 2009-02
期刊: Diabetes care
影响因子: 16.2
作者:
Cowie CC;Rust KF;Ford ES;Eberhardt MS;Byrd-Holt DD;Li C;Williams DE;Gregg EW;Bainbridge KE;Saydah SH;Geiss LS
通讯作者: Geiss LS
DOI: 10.1073/pnas.1000080107
发表时间: 2011-03-15
影响因子: 11.1
作者:
Caporaso, J. Gregory;Lauber, Christian L.;Knight, Rob
通讯作者: Knight, Rob
DOI: 10.1074/mcp.m112.018119
发表时间: 2012-09-01
影响因子: 7
作者:
Garrido, Daniel;Nwosu, Charles;Mills, David A.
通讯作者: Mills, David A.