The human gut microbiome and body metabolism: implications for obesity and diabetes.
The human gut microbiome and body metabolism: implications for obesity and diabetes.
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DOI:
10.1373/clinchem.2012.187617
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发表时间:
2013-04
影响因子:
9.3
通讯作者:
Versalovic J
中科院分区:
文献类型:
--
作者:
Devaraj S;Hemarajata P;Versalovic J
Obesity, metabolic syndrome, and type 2 diabetes are major public health challenges. Recently, interest has surged regarding the possible role of the intestinal microbiota as potential novel contributors to the increased prevalence of these 3 disorders. Recent advances in microbial DNA sequencing technologies have resulted in the widespread application of whole-genome sequencing technologies for metagenomic DNA analysis of complex ecosystems such as the human gut. Current evidence suggests that the gut microbiota affect nutrient acquisition, energy harvest, and a myriad of host metabolic pathways. Advances in the Human Microbiome Project and human metagenomics research will lead the way toward a greater understanding of the importance and role of the gut microbiome in metabolic disorders such as obesity, metabolic syndrome, and diabetes.
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