MtDNA haplogroups M7 and B in southwestern Han Chinese at risk for acute mountain sickness.
MtDNA haplogroups M7 and B in southwestern Han Chinese at risk for acute mountain sickness.
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DOI：
10.1016/j.mito.2011.02.003
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发表时间：
2011-07
期刊：
影响因子：
4.4
通讯作者：
Qian, Gui-Sheng
中科院分区：
文献类型：
--
作者：
Li, Fu-Xiang;Ji, Fu-Yun;Zheng, Shi-Zhen;Yao, Wei;Xiao, Zhen-Liang;Qian, Gui-Sheng
我们进行了一项病例对照研究，旨在调查中国西南部 (SW) 汉族人中线粒体 DNA (mtDNA) 单倍群与急性高山病 (AMS) 的关联。 Pearson 卡方检验或 Fisher 精确检验显示，与非 AMS 受试者相比，AMS 受试者中 mtDNA 单倍群 D 和 M9 显着减少，而单倍群 M7 显着增加。调整体重指数（BMI）（本研究中AMS的危险因素）后的多变量逻辑回归分析显示，D和M9均与AMS风险显着降低相关，而M7与AMS风险显着增加相关（分别为OR = 0.605，p = 0.000；OR = 0.037，p = 0.001；OR = 2.419，p = 0.001）。此外，按 AMS 严重程度分层的进一步分析表明，单倍群 B 与发生严重 AMS 的风险增加 2.41 倍相关（95%C.I = 1.288–4.514，p = 0.006）。我们的研究结果证明，在西南汉族人中，线粒体DNA单倍群D和M9与个体对AMS的耐受性有关，而单倍群M7和B是AMS的危险因素。
We conducted a case-control study to investigate the association of mitochondrial DNA (mtDNA) haplogroups with acute mountain sickness (AMS) in Han Chinese from southwestern (SW) China. Pearson’s chi-square test or Fisher’s exact test revealed significant reduction of mtDNA haplogroups D and M9, while a significant increase of haplogroup M7 in AMS subjects compared with non-AMS subjects. The multivariate logistic regression analysis after adjustment for body mass index (BMI), a risk factor of AMS in the present study, showed that both D and M9 were associated with significantly decreased risk of AMS, while M7 was associated with a significantly increased risk of AMS (OR = 0.605, p = 0.000; OR = 0.037, p = 0.001, and OR = 2.419, p = 0.001, respectively). In addition, the further analysis stratified by the AMS severities indicated that haplogroup B was correlated with a 2.41-folds increased risk of developing severe AMS (95%C.I = 1.288–4.514, p = 0.006). Our findings provide the evidence that, in SW Han Chinese, mtDNA haplogroups D and M9 are related to individual tolerance to AMS, while haplogroups M7 and B are risk factors for AMS.
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影响因子：
56.9
作者：
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通讯作者：
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发表时间：
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