No vacancy: how beneficial microbes cooperate with immunity to provide colonization resistance to pathogens.
No vacancy: how beneficial microbes cooperate with immunity to provide colonization resistance to pathogens.
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DOI：
10.4049/jimmunol.1403169
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发表时间：
2015-05-01
期刊：
影响因子：
--
通讯作者：
Raffatellu M
中科院分区：
文献类型：
--
作者：
Sassone-Corsi M;Raffatellu M
哺乳动物的肠道里有一个由数万亿个微生物组成的群落，统称为肠道微生物群，它们与宿主以互惠互利的关系共同进化。在众多的肠道微生物物种中，已知某些共生细菌在适量施用时可为宿主提供健康益处，因此被标记为“益生菌”。在这里，我们回顾了益生菌和其他有益共生体提供对病原体定植抵抗力的一些机制。相似营养物质的争夺和抗菌剂的细菌分泌提供了有益微生物和有害微生物之间竞争的直接手段。有益微生物还可以通过刺激先天性和适应性免疫的发展以及粘膜屏障的功能来间接减少病原体定植。总而言之，我们收集并提供了证据，证明有益微生物与宿主免疫力合作，努力将病原体拒之门外。
The mammalian intestine harbors a community of trillions of microbes, collectively known as the gut microbiota, which co-evolved with the host in a mutually beneficial relationship. Among the numerous gut microbial species, certain commensal bacteria are known to provide health benefits to the host when administered in adequate amounts, and as such are labeled “probiotics”. Here we review some of the mechanisms by which probiotics and other beneficial commensals provide colonization resistance to pathogens. The battle for similar nutrients and the bacterial secretion of antimicrobials provide a direct means of competition between beneficial and harmful microbes. Beneficial microbes can also indirectly diminish pathogen colonization by stimulating the development of innate and adaptive immunity as well as the function of the mucosal barrier. Altogether, we gather and present evidence that beneficial microbes cooperate with host immunity in an effort to shut out pathogens.
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影响因子：
64.8
作者：
Brandl, Katharina;Plitas, George;Mihu, Coralia N.;Ubeda, Carles;Jia, Ting;Fleisher, Martin;Schnabl, Bernd;DeMatteo, Ronald P.;Pamer, Eric G.
通讯作者：
Pamer, Eric G.
影响因子：
5.4
作者：
Behnsen, Judith;Deriu, Elisa;Raffatellu, Manuela
通讯作者：
Raffatellu, Manuela
DOI：
10.1038/nri3535
发表时间：
2013-11
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.7
作者：
Diaz-Ochoa VE;Jellbauer S;Klaus S;Raffatellu M
通讯作者：
Raffatellu M
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K