Applications of plant viruses in bionanotechnology.

Applications of plant viruses in bionanotechnology.
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DOI:
10.1007/82_2011_184
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发表时间:
2014
影响因子:
--
通讯作者:
Evans DJ
Evans DJ
中科院分区:
医学3区
文献类型:
--
作者:
Lomonossoff GP;Evans DJ

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大多数植物病毒的衣壳是简单而坚固的结构,由一种或几种蛋白质亚基的多个拷贝组成,以二十面体或螺旋对称排列。在许多情况下,衣壳可以通过植物的感染或通过亚基在各种异源系统中的表达来大量产生。鉴于其相对简单、稳定和易于生产,植物病毒颗粒或病毒样颗粒(VLP)作为生物纳米技术应用的潜在试剂而引起了人们的关注。因此,植物病毒颗粒经过了遗传和化学修饰,被用来封装外来物质,并且其本身被纳入超分子结构中。
The capsids of most plant viruses are simple and robust structures consisting of multiple copies of one or a few types of protein subunit arranged with either icosahedral or helical symmetry. In many cases, capsids can be produced in large quantities either by the infection of plants or by the expression of the subunit(s) in a variety of heterologous systems. In view of their relative simplicity, stability and ease of production, plant virus particles or virus-like particles (VLPs) have attracted attention as potential reagents for applications in bionanotechnology. As a result, plant virus particles have been subjected to both genetic and chemical modification, have been used to encapsulate foreign material and have, themselves, been incorporated into supramolecular structures.
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