Transcriptional Regulation of Tetrapyrrole Biosynthesis in Arabidopsis thaliana.
Transcriptional Regulation of Tetrapyrrole Biosynthesis in Arabidopsis thaliana.
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DOI：
10.3389/fpls.2016.01811
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发表时间：
2016
影响因子：
5.6
通讯作者：
Masuda T
中科院分区：
文献类型：
--
作者：
Kobayashi K;Masuda T
叶绿素（Chl）的生物合成涉及许多酶促反应，这些酶促反应与其他四吡咯（如血红素、西罗血红素和藻胆素）的生物合成共享几个第一步骤。叶绿素允许光合生物捕获光能进行光合作用，但同时对细胞造成光氧化损伤的威胁。为了防止叶绿素及其高度光反应中间体的光损伤，光合生物已经开发出多个层次的调节机制，以协调四吡咯生物合成（TPB）与光合和光保护系统的形成，并微调代谢流与不同的需求，叶绿素和其他四吡咯在各种发展和环境条件下。本文综述了植物发育过程中TPB基因的转录调控机制，重点介绍了拟南芥中几种TPB基因的转录调控因子。关键的TPB基因与其他光合相关的核基因紧密共表达，并受光诱导，以昼夜和昼夜节律的方式振荡，与发育和营养状态协调，并响应于叶绿体生物发生的停滞而强烈下调。LONG HYPOCOTYL 5和PHYTOCHROME INTERACTING FACTORS分别是具有广泛光信号传导的正转录因子和负转录因子，靶向许多TPB基因进行光和昼夜节律调节。GOLDEN 2-LIKE转录因子直接调节关键的TPB基因，以微调具有叶绿体功能的光合机构的形成。一些转录因子如FAR-RED ELLONGATED HYPOCOTYL 3、REVEILLE 1和稻草人样转录因子可能直接调控某些特定的TPB基因，而其他转录因子如加塔转录因子可能以间接方式调控TPB基因。全面的TPB基因的转录分析和关键转录调控因子的详细表征，帮助我们获得TPB的转录控制响应环境和内源性线索的全貌。
Biosynthesis of chlorophyll (Chl) involves many enzymatic reactions that share several first steps for biosynthesis of other tetrapyrroles such as heme, siroheme, and phycobilins. Chl allows photosynthetic organisms to capture light energy for photosynthesis but with simultaneous threat of photooxidative damage to cells. To prevent photodamage by Chl and its highly photoreactive intermediates, photosynthetic organisms have developed multiple levels of regulatory mechanisms to coordinate tetrapyrrole biosynthesis (TPB) with the formation of photosynthetic and photoprotective systems and to fine-tune the metabolic flow with the varying needs of Chl and other tetrapyrroles under various developmental and environmental conditions. Among a wide range of regulatory mechanisms of TPB, this review summarizes transcriptional regulation of TPB genes during plant development, with focusing on several transcription factors characterized in Arabidopsis thaliana. Key TPB genes are tightly coexpressed with other photosynthesis-associated nuclear genes and are induced by light, oscillate in a diurnal and circadian manner, are coordinated with developmental and nutritional status, and are strongly downregulated in response to arrested chloroplast biogenesis. LONG HYPOCOTYL 5 and PHYTOCHROME-INTERACTING FACTORs, which are positive and negative transcription factors with a wide range of light signaling, respectively, target many TPB genes for light and circadian regulation. GOLDEN2-LIKE transcription factors directly regulate key TPB genes to fine-tune the formation of the photosynthetic apparatus with chloroplast functionality. Some transcription factors such as FAR-RED ELONGATED HYPOCOTYL3, REVEILLE1, and scarecrow-like transcription factors may directly regulate some specific TPB genes, whereas other factors such as GATA transcription factors are likely to regulate TPB genes in an indirect manner. Comprehensive transcriptional analyses of TPB genes and detailed characterization of key transcriptional regulators help us obtain a whole picture of transcriptional control of TPB in response to environmental and endogenous cues.
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影响因子：
5.6
作者：
Espinas NA;Kobayashi K;Sato Y;Mochizuki N;Takahashi K;Tanaka R;Masuda T
通讯作者：
Masuda T
影响因子：
7.4
作者：
Albus, Christin Anne;Salinas, Annabel;Schoettler, Mark Aurel
通讯作者：
Schoettler, Mark Aurel
影响因子：
7.2
作者：
Chattopadhyay, S;Puente, P;Wei, N
通讯作者：
Wei, N
影响因子：
11.6
作者：
Benhamed, Moussa;Bertrand, Claire;Zhou, Dao-Xiu
通讯作者：
Zhou, Dao-Xiu
影响因子：
7.2
作者：
Acevedo-Hernández, GJ;León, P;Herrera-Estrella, LR
通讯作者：
Herrera-Estrella, LR