A Bacterial Quorum Sensing Molecule Elicits a General Stress Response in Saccharomyces cerevisiae.
A Bacterial Quorum Sensing Molecule Elicits a General Stress Response in Saccharomyces cerevisiae.
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DOI：
10.3389/fmicb.2021.632658
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发表时间：
2021
影响因子：
5.2
通讯作者：
Meijler MM
中科院分区：
文献类型：
--
作者：
Delago A;Gregor R;Dubinsky L;Dandela R;Hendler A;Krief P;Rayo J;Aharoni A;Meijler MM
细菌通过一种称为群体感应的化学通讯机制来评估它们的种群密度，以协调群体行为。大多数关于群体感应的研究主要集中在它作为一种种内化学信号机制的作用上，这种机制可以通过靶向基因表达来调节某些表型。然而，近年来一些开创性的研究揭示了群体感应分子作为物种间信号可能调节微生物生态的重要现象。在这项研究中，我们询问出芽酵母是否能感知来自原核生物的化学信号。当暴露于来自不同细菌种类和白色念珠菌的各种群体感应分子时，我们发现来自机会性人类病原体铜绿假单胞菌的N-（3-氧十二烷基）- l -高丝氨酸内酯（C12）在酵母中诱导了显著的应激反应。微阵列实验证实并帮助解释了这些发现，显示了一种独特而特定的表达模式，与先前描述的应激因素的反应有很大不同。我们进一步表征了这种反应，并报告了酵母识别C12的分子基础的初步发现。
Bacteria assess their population density through a chemical communication mechanism termed quorum sensing, in order to coordinate group behavior. Most research on quorum sensing has focused primarily on its role as an intraspecies chemical signaling mechanism that enables the regulation of certain phenotypes through targeted gene expression. However, in recent years several seminal studies have revealed important phenomena in which quorum sensing molecules appear to serve additional roles as interspecies signals that may regulate microbial ecology. In this study, we asked whether the budding yeast Saccharomyces cerevisiae can sense chemical signals from prokaryotes. When exposed to a variety of quorum sensing molecules from different bacterial species and from Candida albicans we found that N-(3-oxododecanoyl)-L-homoserine lactone (C12) from the opportunistic human pathogen Pseudomonas aeruginosa induces a remarkable stress response in yeast. Microarray experiments confirmed and aided in interpreting these findings, showing a unique and specific expression pattern that differed significantly from the response to previously described stress factors. We further characterized this response and report preliminary findings on the molecular basis for the recognition of C12 by the yeast.
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影响因子：
6.4
作者：
Avni, Dorit;Philosoph, Amir;Zor, Tsaffrir
通讯作者：
Zor, Tsaffrir
DOI：
10.1164/rccm.2206018
发表时间：
2002-12-15
影响因子：
24.7
作者：
Conner, GE;Salathe, M;Forteza, R
通讯作者：
Forteza, R
影响因子：
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作者：
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通讯作者：
Hogan, Deborah A.
影响因子：
3.6
作者：
Davis-Hanna, Amber;Piispanen, Amy E.;Hogan, Deborah A.
通讯作者：
Hogan, Deborah A.
影响因子：
2.9
作者：
Gasch, Audrey P;Werner-Washburne, Margaret
通讯作者：
Werner-Washburne, Margaret