Internal doses in experimental mice and rats following exposure to neutron-activated (56)MnO(2) powder: results of an international, multicenter study.
Internal doses in experimental mice and rats following exposure to neutron-activated (56)MnO(2) powder: results of an international, multicenter study.
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DOI：
10.1007/s00411-020-00870-x
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发表时间：
2020-11
影响因子：
1.7
通讯作者：
Hoshi M
中科院分区：
文献类型：
--
作者：
Stepanenko V;Kaprin A;Ivanov S;Shegay P;Zhumadilov K;Petukhov A;Kolyzhenkov T;Bogacheva V;Zharova E;Iaskova E;Chaizhunusova N;Shabdarbayeva D;Amantayeva G;Baurzhan A;Ruslanova B;Abishev Z;Apbassova M;Kairkhanova Y;Uzbekov D;Khismetova Z;Zhunussov Y;Fujimoto N;Sato H;Shichijo K;Nakashima M;Sakaguchi A;Toyoda S;Kawano N;Ohtaki M;Otani K;Endo S;Yamamoto M;Hoshi M
进行这项实验是为了支持日本的一项倡议，即调查原子弹爆炸产生的剩余中子活化放射性辐射的生物效应。放射性核素56 Mn（T1/2 = 2.58 h）是土壤尘埃粒子中子活化后最初几个小时内的主要中子活化发射体之一。在我们之前的研究（2016-2017年）中，发现在分散56 MnO 2粉末后对雄性Wistar大鼠进行辐照，大鼠体内的内部剂量非常不均匀：不同器官之间的剂量分布范围从小肠的1.3戈伊到其他一些器官的小于0.0015戈伊。肺内剂量范围为0.03至0.1戈伊。低剂量照射后大鼠肺组织出现了实质性的病理改变。在本研究中，剂量学的调查进行了扩展：内部剂量在实验小鼠和大鼠的各种活动水平的分散中子活化56 MnO 2粉末估计。注意到以下结果：（a）在类似的暴露于56 MnO 2粉末的条件下，小鼠体内辐射剂量比大鼠高出数倍。(b)将2.74 × 108 Bq的56 MnO_2粉末分散在小鼠身上，胃肠道（小肠、胃、大肠）内照射剂量范围为0.81 ~ 4.5戈伊，肺内照射剂量范围为0.096 ~ 0.14戈伊，皮肤和眼睛内照射剂量范围分别为0.29 ~ 0.42戈伊和0.12 ~ 0.16戈伊。小鼠其他器官的内部辐射剂量要低得多。(c)暴露于56 MnO 2粉末（2.74 × 108 Bq）相同活性的大鼠器官的内辐射剂量明显较低：胃、小肠、大肠和肺分别为0.09、0.17、0.29和0.025戈伊。(d)大鼠和小鼠接受8.0 × 108 Bq的~（56）MnO_2内照射，其器官内照射剂量比接受2.74 × 108 Bq的~（56）MnO_2内照射高2 ~ 4倍。(e)与最高剂量8.0 × 108 Bq的56MnO_2粉末相比，最低剂量8.0 × 107 Bq的56MnO_2粉末在小鼠器官中的内照射剂量低7-14倍。获得的数据将用于解释实验小鼠和大鼠中的生物效应，这些生物效应是由不同水平的中子活化56 MnO 2粉末分散引起的，这是单独研究的主题。
The experiment was performed in support of a Japanese initiative to investigate the biological effects of irradiation from residual neutron-activated radioactivity that resulted from the A-bombing. Radionuclide 56Mn (T1/2 = 2.58 h) is one of the main neutron-activated emitters during the first hours after neutron activation of soil dust particles. In our previous studies (2016–2017) related to irradiation of male Wistar rats after dispersion of 56MnO2 powder, the internal doses in rats were found to be very inhomogeneous: distribution of doses among different organs ranged from 1.3 Gy in small intestine to less than 0.0015 Gy in some of the other organs. Internal doses in the lungs ranged from 0.03 to 0.1 Gy. The essential pathological changes were found in lung tissue of rats despite a low level of irradiation. In the present study, the dosimetry investigations were extended: internal doses in experimental mice and rats were estimated for various activity levels of dispersed neutron-activated 56MnO2 powder. The following findings were noted: (a) internal radiation doses in mice were several times higher in comparison with rats under similar conditions of exposure to 56MnO2 powder. (b) When 2.74 × 108 Bq of 56MnO2 powder was dispersed over mice, doses of internal irradiation ranged from 0.81 to 4.5 Gy in the gastrointestinal tract (small intestine, stomach, large intestine), from 0.096 to 0.14 Gy in lungs, and doses in skin and eyes ranged from 0.29 to 0.42 Gy and from 0.12 to 0.16 Gy, respectively. Internal radiation doses in other organs of mice were much lower. (c) Internal radiation doses were significantly lower in organs of rats with the same activity of exposure to 56MnO2 powder (2.74 × 108 Bq): 0.09, 0.17, 0.29, and 0.025 Gy in stomach, small intestine, large intestine, and lungs, respectively. (d) Doses of internal irradiation in organs of rats and mice were two to four times higher when they were exposed to 8.0 × 108 Bq of 56MnO2 (in comparison with exposure to 2.74 × 108 Bq of 56MnO2). (e) Internal radiation doses in organs of mice were 7–14 times lower with the lowest 56MnO2 amount (8.0 × 107 Bq) in comparison with the highest amount, 8.0 × 108 Bq, of dispersed 56MnO2 powder. The data obtained will be used for interpretation of biological effects in experimental mice and rats that result from dispersion of various levels of neutron-activated 56MnO2 powder, which is the subject of separate studies.
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影响因子：
9.3
作者：
Bolch, Wesley E.;Eckerman, Keith F.;Thomas, Stephen R.
通讯作者：
Thomas, Stephen R.
影响因子：
1.7
作者：
Tanaka, Kenichi;Endo, Satoru;Hoshi, Masaharu
通讯作者：
Hoshi, Masaharu
影响因子：
1.7
作者：
Shichijo K;Fujimoto N;Uzbekov D;Kairkhanova Y;Saimova A;Chaizhunusova N;Sayakenov N;Shabdarbaeva D;Aukenov N;Azimkhanov A;Kolbayenkov A;Mussazhanova Z;Niino D;Nakashima M;Zhumadilov K;Stepanenko V;Tomonaga M;Rakhypbekov T;Hoshi M
通讯作者：
Hoshi M
影响因子：
1
作者：
Imanaka, Tetsuji;Endo, Satoru;Tanaka, Kenichi
通讯作者：
Tanaka, Kenichi
影响因子：
2.2
作者：
Kerr, George D.;Egbert, Stephen D.;Young, Robert W.
通讯作者：
Young, Robert W.