Bisphenol A and peripheral arterial disease: results from the NHANES.
Bisphenol A and peripheral arterial disease: results from the NHANES.
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DOI：
10.1289/ehp.1104114
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发表时间：
2012-09
影响因子：
10.4
通讯作者：
Sabanayagam C
中科院分区：
文献类型：
--
作者：
Shankar A;Teppala S;Sabanayagam C
背景：双酚A （BPA）是一种用于制造聚碳酸酯塑料和环氧树脂的常见化学物质，大约93%的美国成年人尿液中可检测到BPA。最近的动物研究表明，BPA暴露可能在心血管疾病（CVD）发展的几个机制中起作用，包括体重增加、胰岛素抵抗、甲状腺功能障碍、内皮功能障碍和氧化应激。然而，很少有人研究BPA暴露与心血管疾病之间的关系。外周动脉疾病（PAD）是动脉粥样硬化性血管疾病的亚临床指标，也是心血管疾病和死亡率的一个强大的独立危险因素。目的：我们研究了美国成年人尿液中BPA水平与PAD之间的关系。方法：我们分析了2003-2004年全国健康和营养检查调查中745名参与者的数据。我们使用logistic回归模型对潜在混杂因素（年龄、性别、种族/民族、教育程度、吸烟、体重指数、糖尿病、高血压、尿肌酐、肾小球滤过率和血清胆固醇水平）进行校正，估计尿中BPA水平（以三分之一为单位）和PAD（踝-肱指数< 0.9,n = 63）之间的关联。结果：我们观察到，在调整混杂因素前后，尿液BPA水平升高与PAD之间存在显著的正相关。尿中BPA含量最高和最低与PAD相关的多变量校正比值比为2.69（95%可信区间：1.02,7.09;p-trend = 0.01）。结论：尿中BPA水平与PAD显著相关，独立于传统心血管疾病危险因素。
Background: Bisphenol A (BPA) is a common chemical used in the manufacture of polycarbonate plastics and epoxy resins, and > 93% of U.S. adults have detectable levels of urinary BPA. Recent animal studies have suggested that BPA exposure may have a role in several mechanisms involved in the development of cardiovascular disease (CVD), including weight gain, insulin resistance, thyroid dysfunction, endothelial dysfunction, and oxidative stress. However, few human studies have examined the association between markers of BPA exposure and CVD. Peripheral arterial disease (PAD) is a subclinical measure of atherosclerotic vascular disease and a strong independent risk factor for CVD and mortality. Objective: We examined the association between urinary BPA levels and PAD in a nationally representative sample of U.S. adults. Methods: We analyzed data from 745 participants in the National Health and Nutritional Examination Survey 2003–2004. We estimated associations between urinary BPA levels (in tertiles) and PAD (ankle–brachial index < 0.9, n = 63) using logistic regression models adjusted for potential confounders (age, sex, race/ethnicity, education, smoking, body mass index, diabetes mellitus, hypertension, urinary creatinine, estimated glomerular filtration rate, and serum cholesterol levels). Results: We observed a significant, positive association between increasing levels of urinary BPA and PAD before and after adjusting for confounders. The multivariable-adjusted odds ratio for PAD associated with the highest versus lowest tertile of urinary BPA was 2.69 (95% confidence interval: 1.02, 7.09; p-trend = 0.01). Conclusions: Urinary BPA levels were significantly associated with PAD, independent of traditional CVD risk factors.
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影响因子：
4.1
作者：
Rubin BS;Soto AM
通讯作者：
Soto AM
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
--
作者：
Murabito, JM;Evans, JC;Wilson, PWF
通讯作者：
Wilson, PWF
DOI：
10.1016/j.bbrc.2008.06.050
发表时间：
2008-08-29
影响因子：
3.1
作者：
Matsushima, Ayami;Teramoto, Takamasa;Shimohigashi, Yasuyuki
通讯作者：
Shimohigashi, Yasuyuki
影响因子：
10.4
作者：
Alonso-Magdalena P;Morimoto S;Ripoll C;Fuentes E;Nadal A
通讯作者：
Nadal A