HIV antibodies for treatment of HIV infection.
HIV antibodies for treatment of HIV infection.
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DOI：
10.1111/imr.12506
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发表时间：
2017-01
影响因子：
8.7
通讯作者：
Ferrari G
中科院分区：
文献类型：
--
作者：
Margolis DM;Koup RA;Ferrari G
改进目前高效、安全和简单的联合抗逆转录病毒疗法（ART）的门槛很高。然而，结合HIV包膜的抗体能够独特地靶向病毒，因为它试图进入新的靶细胞，或者因为它从先前感染的细胞表达。此外，使用针对HIV的抗体作为治疗剂可以提供优势。抗体可以具有长的半衰期，并且被认为是用于治疗或预防HIV感染的长效抗逆转录病毒药物的伙伴。在动物模型和临床试验中的早期研究表明，这种抗体可以具有抗病毒活性，但与小分子抗逆转录病毒药物一样，病毒逃逸和耐药性的问题必须得到解决。然而，最有希望的是抗HIV抗体的独特性质：调理病毒颗粒的潜在能力，直接抗体依赖性细胞毒性（ADCC）针对活跃感染的细胞，并最终通过免疫系统的效应细胞直接清除HIV感染的细胞的能力。这些独特的活性表明，HIV抗体及其衍生物可能在HIV治疗的下一个前沿领域发挥重要作用，即开发可能导致HIV治愈的治疗方法。
The bar is high to improve on current combination antiretroviral therapy (ART), now highly effective, safe, and simple. However antibodies that bind the HIV envelope are able to uniquely target the virus as it seeks to enter new target cells, or as it is expressed from previously infected cells. Further, the use of antibodies against HIV as a therapeutic may offer advantages. Antibodies can have long half-lives, and are being considered as partners for long-acting antiretrovirals for use in therapy or prevention of HIV infection. Early studies in animal models and in clinical trials suggest that such antibodies can have antiviral activity but, as with small molecule antiretrovirals, the issues of viral escape and resistance will have to be addressed. Most promising, however, are the unique properties of anti-HIV antibodies: the potential ability to opsonize viral particles, to direct antibody-dependent cellular cytotoxicity (ADCC) against actively infected cells, and ultimately the ability to direct the clearance of HIV-infected cells by effector cells of the immune system. These distinctive activities suggest that HIV antibodies and their derivatives may play an important role in the next frontier of HIV therapeutics, the effort to develop treatments that could lead to an HIV cure.
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
11.1
作者：
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