Predicting response to leuprolide of women with premenstrual dysphoric disorder by daily mood rating dynamics.
Predicting response to leuprolide of women with premenstrual dysphoric disorder by daily mood rating dynamics.
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通过日常情绪评级动态预测患有经前焦虑症的女性对亮丙瑞林的反应。
DOI：
10.1016/j.jpsychires.2010.07.006
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发表时间：
2011
影响因子：
4.8
通讯作者：
Schmidt,PeterJ
中科院分区：
文献类型：
--
作者：
Pincus,StevenM;Alam,Shaista;Rubinow,DavidR;Bhuvaneswar,ChayaG;Schmidt,PeterJ
大约60- 70%的经前焦虑障碍（PMDD）女性对GnRH激动剂醋酸亮丙瑞林（抑制卵巢功能）的反应显示症状改善。然而，很难预测或理解为什么有些妇女作出反应，而另一些妇女则没有。我们应用了几种互补的统计方法的动态治疗前的情绪评级数据，以确定可能的预测因子与PMDD的妇女的反应。我们在亮丙瑞林（持续3个月）治疗PMDD的临床试验中比较了应答者（n = 33）和无应答者（n = 12），基于试验前每日悲伤、焦虑和易怒的自我评定。我们分析了连续的不规则性（近似熵，ApEn）和这些系列的尖峰的量化，以及同等加权这两个统计量的综合措施。应答者的ApEn和Spikiness均显著小于无应答者（P≤0.005）;应答者的复合指标小于无应答者（P≤0.002），并区分了具有高灵敏度和特异性的亚组。相反，亚组之间的平均症状水平不明显。情绪评级的相对规律和非尖峰试验前动态预测PMDD女性对亮丙瑞林的积极反应的可能性很高，而且通常基于不到3个月的每日记录。统计措施可能有广泛的和直接的适用性，许多精神疾病的行为研究，促进准确的诊断和治疗反应的预测。
Approximately 60–70 percent of women with premenstrual dysphoric disorder (PMDD) show symptomatic improvement in response to the GnRH agonist leuprolide acetate, which suppresses ovarian function. However, it has been very difficult to either predict or understand why some women respond, while others do not. We applied several complementary statistical methods to the dynamics of pre-treatment mood rating data to determine possible predictors of response for women with PMDD. We compared responders (n = 33) to nonresponders (n = 12) in clinical trials of leuprolide (three months in duration) as a treatment for PMDD, on the basis of pre-trial daily self-ratings of sadness, anxiety, and irritability. We analyzed both sequential irregularity (approximate entropy, ApEn) and a quantification of spikiness of these series, as well as a composite measure that equally weighted these two statistics. Both ApEn and Spikiness were significantly smaller for responders than nonresponders (P≤0.005); the composite measure was smaller for responders compared with nonresponders (P≤0.002) and discriminated between the subgroups with high sensitivity and specificity. In contrast, mean symptom levels were indistinct between the subgroups. Relatively regular and non-spiky pre-trial dynamics of mood ratings predict a positive response to leuprolide by women with PMDD with high probability, moreover based on typically less than 3 months of daily records. The statistical measures may have broad and direct applicability to behavioral studies for many psychiatric disorders, facilitating both accurate diagnosis and the prediction of response to treatment.
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月经相关情绪障碍的前瞻性评估。
DOI：
10.1176/ajp.141.5.684
发表时间：
1984
期刊：
The American journal of psychiatry
影响因子：
--
作者：
David R. Rubinow;Peter Roy;M. Hoban;Philip W. Gold;Robert M. Post
通讯作者：
Robert M. Post
达那唑治疗经前综合症的随机、安慰剂对照、交叉试验
影响因子：
3.7
作者：
P. Hahn;D. A. Vugt;R. Reid
通讯作者：
R. Reid
前瞻性定义的经前综合症的一些相关性。
DOI：
10.1176/ajp.145.4.491
发表时间：
1988
期刊：
The American journal of psychiatry
影响因子：
--
作者：
P. Schnurr
通讯作者：
P. Schnurr
经前期综合症：“医学卵巢切除术”的影响
影响因子：
6.2
作者：
K. Muse;N. Cetel;L. A. Futterman;S. Yen
通讯作者：
S. Yen
新型低剂量口服避孕药屈螺酮治疗经前焦虑症的疗效
影响因子：
7.2
作者：
K. Yonkers;Candace S. Brown;T. Pearlstein;M. Foegh;Carole Sampson;A. Rapkin
通讯作者：
A. Rapkin