Surface Electric Fields Increase Human Osteoclast Resorption through Improved Wettability on Carbonate-Incorporated Apatite.
Surface Electric Fields Increase Human Osteoclast Resorption through Improved Wettability on Carbonate-Incorporated Apatite.
复制标题
表面电场通过改善碳酸盐磷灰石的润湿性来增加人类破骨细胞的再吸收。
DOI：
10.1021/acsami.1c14358
复制
发表时间：
2021-12-15
影响因子：
9.5
通讯作者：
Nakamura M
中科院分区：
文献类型：
--
作者：
Bergara-Muguruza L;Mäkelä K;Yrjälä T;Salonen J;Yamashita K;Nakamura M
破骨细胞介导的生物吸收可以是将生物材料溶解纳入骨重建过程的有效手段。由于生物材料的组成和结构与骨基质的天然矿物相非常相似，合成碳酸盐取代磷灰石（CA）被认为是临床使用的理想生物材料。因此，本研究探讨了电极化对羟基磷灰石（HA）和CA的表面特性和与人破骨细胞的相互作用的影响。发现电极化通过增加表面自由能来改善这些材料的表面润湿性，并且这种效果维持1个月。人破骨细胞培养物的分析确定，CA进行极化处理增强破骨细胞的再吸收，但不影响早期分化阶段或粘附形态的破骨细胞的染色评价。这些数据表明，CA的表面特性促进破骨细胞吸收。这项工作的结果预计将有助于未来的细胞介导的生物可吸收的生物材料的破骨细胞的吸收能力，并作为骨再生的支架设计。
Osteoclast-mediated bioresorption can be an efficient means of incorporating the dissolution of biomaterials in the bone remodeling process. Because of the compositionally and structurally close resemblance of biomaterials with the natural mineral phases of the bone matrix, synthetic carbonate-substituted apatite (CA) is considered as an ideal biomaterial for clinical use. The present study therefore investigated the effects of electrical polarization on the surface characteristics and interactions with human osteoclasts of hydroxyapatite (HA) and CA. Electrical polarization was found to improve the surface wettability of these materials by increasing the surface free energy, and this effect was maintained for 1 month. Analyses of human osteoclast cultures established that CA subjected to a polarization treatment enhanced osteoclast resorption but did not affect the early differentiation phase or the adherent morphology of the osteoclasts as evaluated by staining. These data suggest that the surface characteristics of the CA promoted osteoclast resorption. The results of this work are expected to contribute to the future design of cell-mediated bioresorbable biomaterials capable of resorption by osteoclasts and of serving as a scaffold for bone regeneration.
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DOI：
10.1016/s1389-0344(02)00023-0
发表时间：
2002-08-01
期刊：
BIOMOLECULAR ENGINEERING
影响因子：
--
作者：
Monchau, F;Lefèvre, A;Hildebrand, HF
通讯作者：
Hildebrand, HF
影响因子：
4.2
作者：
Husheem, M;Nyman, JKE;Hentunen, TA
通讯作者：
Hentunen, TA
影响因子：
9.7
作者：
Bodhak, Subhadip;Bose, Susmita;Bandyopadhyay, Amit
通讯作者：
Bandyopadhyay, Amit
影响因子：
8.2
作者：
Eriksen, Erik Fink
通讯作者：
Eriksen, Erik Fink
影响因子：
5.9
作者：
FALCHUK, KH;GOETZL, EJ;KULKA, JP
通讯作者：
KULKA, JP