A brief account of nanoparticle contrast agents for photoacoustic imaging.
A brief account of nanoparticle contrast agents for photoacoustic imaging.
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DOI：
10.1002/wnan.1231
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发表时间：
2013-11
影响因子：
8.6
通讯作者：
Lanza, Gregory M.
中科院分区：
文献类型：
--
作者：
Pan, Dipanjan;Kim, Benjamin;Wang, Lihong V.;Lanza, Gregory M.
光声成像（派）是一种混合的非电离模式，提供出色的空间分辨率，深穿透和高软组织对比度。在派中，基于内源性组织或外源性造影剂对激光产生的光能的吸收产生信号，导致超声换能器检测到声发射。多年来在该领域的研究表明，派具有提供生理和分子成像的能力，可以单独观察或以混合模态方式使用，以扩展临床超声的解剖学和血液动力学灵敏度。派可以使用由光吸收分子（例如血红蛋白、肌红蛋白和黑色素）或外源性小分子造影剂（例如近红外染料和卟啉）提供的固有对比度来进行。然而，这篇综述总结了潜在的外源性纳米颗粒为基础的代理派应用，包括对比金颗粒，碳纳米管，和封装的铜化合物。
Photoacoustic imaging (PAI) is a hybrid, nonionizing modality offering excellent spatial resolution, deep penetration, and high soft tissue contrast. In PAI, signal is generated based on the absorption of laser-generated optical energy by endogenous tissues or exogenous contrast agents leading to acoustic emissions detected by an ultrasound transducer. Research in this area over the years has shown that PAI has the ability to provide both physiological and molecular imaging, which can be viewed alone or used in a hybrid modality fashion to extend the anatomic and hemodynamic sensitivities of clinical ultrasound. PAI may be performed using inherent contrast afforded by light absorbing molecules such as hemoglobin, myoglobin, and melanin or exogenous small molecule contrast agent such as near infrared dyes and porphyrins. However, this review summarizes the potential of exogenous nanoparticle-based agents for PAI applications including contrast based on gold particles, carbon nanotubes, and encapsulated copper compounds.
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影响因子：
19
作者：
Chen J;Yang M;Zhang Q;Cho EC;Cobley CM;Kim C;Glaus C;Wang LV;Welch MJ;Xia Y
通讯作者：
Xia Y
影响因子：
3.6
作者：
Hoelen, CGA;de Mul, FFM;Dekker, A
通讯作者：
Dekker, A
DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hirsch, LR;Stafford, RJ;West, JL
通讯作者：
West, JL
DOI：
10.1073/pnas.93.18.9764
发表时间：
1996-09-03
影响因子：
11.1
作者：
Friedlander, M;Theesfeld, CL;Cheresh, DA
通讯作者：
Cheresh, DA
影响因子：
56.9
作者：
BROOKS, PC;CLARK, RAF;CHERESH, DA
通讯作者：
CHERESH, DA