Advances in understanding cell interactions in tissue resorption. Relevance to the pathogenesis of periodontal diseases and a new hypothesis.
Advances in understanding cell interactions in tissue resorption. Relevance to the pathogenesis of periodontal diseases and a new hypothesis.
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了解组织吸收中细胞相互作用的进展。
DOI：
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
J. Reynolds
中科院分区：
文献类型：
--
作者：
M. Meikle;J. Heath;J. Reynolds
牙周病中发生的结缔组织降解大部分是由蛋白水解酶介导的。以往的研究主要集中在入侵多形核中性粒细胞和巨噬细胞释放的蛋白酶以及细菌酶的作用上。鉴于最近的研究表明，细胞因子可以诱导常驻结缔组织细胞破坏其自身基质，我们提出了一个新的假设。在这方面，我们设想一个关键步骤是细菌抗原与炎症细胞的相互作用，导致细胞因子，白细胞介素-1的产生。我们对体外证据的解释是，牙周病中结缔组织附着和骨基质吸收的丧失是由牙周组织细胞释放的胶原酶和基质溶解素等金属蛋白酶介导的。这种蛋白水解破坏可以由白细胞介素-1诱导，白细胞介素-1的产生可能不依赖于特定的微生物菌群，但可能由许多生物体触发。现在很清楚，白细胞介素-1对免疫细胞和非免疫细胞有多种作用；这些作用包括诱导淋巴细胞分化和增殖，刺激骨和软骨吸收，以及结缔组织合成前列腺素和金属蛋白酶。似乎进一步了解这种细胞因子的产生和功能将对许多涉及吸收的疾病产生越来越大的影响，特别是因为白细胞介素-1样分子可以由单核/巨噬细胞以外的细胞类型产生，包括角化细胞和成纤维细胞。
Much of the connective tissue degradation that takes place in periodontal diseases is mediated by proteolytic enzymes. Previous studies have focused on the action of proteinases released by invading polymorphonuclear neutrophils and macrophages, and bacterial enzymes. In view of recent work establishing that resident connective tissue cells can be induced by cytokines to bring about the destruction of their own matrix, we propose a new hypothesis. In this we envisage that a critical step is the interaction of bacterial antigens with inflammatory cells, resulting in the production of a cytokine, interleukin-1. Our interpretation of in vitro evidence is that the loss of connective tissue attachment and bone matrix resorption in periodontal diseases is mediated by metalloproteinases such as collagenase and stromelysin released by cells of the periodontium. Such proteolytic destruction can be induced by interleukin-1, whose production may not be dependent on a specific microbial flora but may be triggered by a number of organisms. It is now clear that interleukin-1 has multiple actions on both immune and non-immune cells; these include the induction of lymphocyte differentiation and proliferation and the stimulation of bone and cartilage resorption, and prostaglandin and metalloproteinase synthesis by connective tissues. It seems likely that further knowledge about the production and function of this cytokine will have an increasing impact in many diseases that involve resorption, particularly since interleukin-1-like molecules can be produced by cell types other than monocytes/macrophages, including keratinocytes and fibroblasts.
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潜伏胶原酶的前体形式，在无细胞系统中使用来自兔滑膜细胞的 mRNA 产生。
DOI：
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发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Nagase,H;Jackson,RC;Brinckerhoff,CE;Vater,CA;HarrisJr,ED
通讯作者：
HarrisJr,ED
影响因子：
3.5
作者：
Passo,SA;Tsai,CC;McArthur,WP;Leifer,C;Taichman,NS
通讯作者：
Taichman,NS
DOI：
10.1073/pnas.81.24.7907
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
AURON, PE;WEBB, AC;DINARELLO, CA
通讯作者：
DINARELLO, CA
影响因子：
3.5
作者：
GOLUB, LM;LEE, HM;RAMAMURTHY, NS
通讯作者：
RAMAMURTHY, NS
影响因子：
3.5
作者：
GOLUB, LM;WOLFF, M;CIANCIO, S
通讯作者：
CIANCIO, S