Disrupted topological organization in whole-brain functional networks of heroin-dependent individuals: a resting-state FMRI study.
Disrupted topological organization in whole-brain functional networks of heroin-dependent individuals: a resting-state FMRI study.
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海洛因依赖者全脑功能网络拓扑组织破坏：静息态功能磁共振成像研究
DOI：
10.1371/journal.pone.0082715
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Huang R
中科院分区：
文献类型：
--
作者：
Jiang G;Wen X;Qiu Y;Zhang R;Wang J;Li M;Ma X;Tian J;Huang R
神经成像研究表明，海洛因成瘾与广泛的局部区域和大脑功能连接的异常有关。然而，人们对海洛因成瘾是否会改变全脑功能网络的拓扑结构知之甚少。选取17名海洛因依赖者（hdi）和15名年龄、性别匹配的正常对照（nc），采集静息态功能磁共振成像（RS-fMRI）。我们构建了hdi和nc的脑功能网络，并利用图论方法比较了组间网络拓扑性质的差异。我们发现，与nc相比，hdi的归一化聚类系数和小世界性都有所降低。此外，HDIs主要表现出认知控制网络区域（包括双侧中扣带回、左侧额叶中回和右侧楔前叶）的节点中心性显著降低，但主要表现为左侧海马的节点中心性显著增加。组间节点中心性的差异没有通过多次比较得到纠正，这表明这些应被视为探索性分析。此外，左侧海马节中心性与海洛因成瘾持续时间呈正相关。总的来说，我们的研究结果表明hdi的全脑功能网络发生破坏，这可能有助于进一步了解海洛因成瘾的机制。
Neuroimaging studies have shown that heroin addiction is related to abnormalities in widespread local regions and in the functional connectivity of the brain. However, little is known about whether heroin addiction changes the topological organization of whole-brain functional networks. Seventeen heroin-dependent individuals (HDIs) and 15 age-, gender-matched normal controls (NCs) were enrolled, and the resting-state functional magnetic resonance images (RS-fMRI) were acquired from these subjects. We constructed the brain functional networks of HDIs and NCs, and compared the between-group differences in network topological properties using graph theory method. We found that the HDIs showed decreases in the normalized clustering coefficient and in small-worldness compared to the NCs. Furthermore, the HDIs exhibited significantly decreased nodal centralities primarily in regions of cognitive control network, including the bilateral middle cingulate gyrus, left middle frontal gyrus, and right precuneus, but significantly increased nodal centralities primarily in the left hippocampus. The between-group differences in nodal centralities were not corrected by multiple comparisons suggesting these should be considered as an exploratory analysis. Moreover, nodal centralities in the left hippocampus were positively correlated with the duration of heroin addiction. Overall, our results indicated that disruptions occur in the whole-brain functional networks of HDIs, findings which may be helpful in further understanding the mechanisms underlying heroin addiction.
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DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
影响因子：
3.4
作者：
Ersche, Karen D.;Fletcher, Paul C.;Roiser, Jonathan P.;Fryer, Tim D.;London, Mervyn;Robbins, Trevor W.;Sahakian, Barbara J.
通讯作者：
Sahakian, Barbara J.
DOI：
10.1093/brain/awm255
发表时间：
2008-05
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Henriksen G;Willoch F
通讯作者：
Willoch F
影响因子：
4.3
作者：
Kaiser, Marcus;Hilgetag, Claus C
通讯作者：
Hilgetag, Claus C