Fezf1 and Fezf2 are required for olfactory development and sensory neuron identity.
Fezf1 and Fezf2 are required for olfactory development and sensory neuron identity.
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DOI：
10.1002/cne.22596
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发表时间：
2011-07-01
影响因子：
2.5
通讯作者：
Chen, Bin
中科院分区：
文献类型：
--
作者：
Eckler, Matthew J.;McKenna, William L.;Taghvaei, Sahar;McConnell, Susan K.;Chen, Bin
鼠类嗅觉系统由执行不同和重叠功能的主要系统和辅助系统组成。主嗅上皮（莫伊）主要参与挥发性气味的检测，而犁鼻器（VNO）中的神经元，辅助嗅觉系统的一部分，是重要的信息素检测。在发育过程中，莫伊和VNO都起源于嗅窝，然而，调节这些解剖学上不同的器官从共同的嗅原基发育的机制尚不清楚。在这里，我们报告，两个密切相关的锌指转录因子FEZF 1和FEZF 2调节莫伊感觉神经元的身份和VNO神经元的生存分别是必不可少的。Fezf1主要在莫伊中表达，而Fezf2的表达仅限于VNO。在Fezf1缺陷小鼠中，嗅觉神经元不能成熟，并且还表达功能性VNO神经元的标记物。在Fezf2缺陷小鼠中，VNO神经元在出生前退化。这些结果确定Fezf1和Fezf2作为嗅觉系统发育和感觉神经元身份的重要调节剂。
The murine olfactory system consists of main and accessory systems that perform distinct and overlapping functions. The main olfactory epithelium (MOE) is primarily involved in the detection of volatile odorants, while neurons in the vomeronasal organ (VNO), part of the accessory olfactory system, are important for pheromone detection. During development, the MOE and VNO both originate from the olfactory pit, however, the mechanisms regulating development of these anatomically distinct organs from a common olfactory primordium are unknown. Here we report that two closely related zinc-finger transcription factors FEZF1 and FEZF2 regulate the identity of MOE sensory neurons and are essential for the survival of VNO neurons respectively. Fezf1 is predominantly expressed in the MOE while Fezf2 expression is restricted to the VNO. In Fezf1 deficient mice, olfactory neurons fail to mature and also express markers of functional VNO neurons. In Fezf2 deficient mice, VNO neurons degenerate prior to birth. These results identify Fezf1 and Fezf2 as important regulators of olfactory system development and sensory neuron identity.
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影响因子：
64.8
作者：
LUO, Y;HURWITZ, J;MASSAGUE, J
通讯作者：
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影响因子：
16.2
作者：
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DOI：
10.1073/pnas.0509032102
发表时间：
2005-12-06
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11.1
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作者：
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通讯作者：
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影响因子：
2.5
作者：
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通讯作者：
Firestein, Stuart