Neurobiology of fibromyalgia and chronic widespread pain.
Neurobiology of fibromyalgia and chronic widespread pain.
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DOI：
10.1016/j.neuroscience.2016.06.006
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发表时间：
2016-12-03
期刊：
影响因子：
3.3
通讯作者：
Clauw, Daniel J.
中科院分区：
文献类型：
--
作者：
Sluka, Kathleen A.;Clauw, Daniel J.
纤维肌痛是目前的术语慢性广泛的肌肉骨骼疼痛，没有其他原因可以确定。本文将探讨人类和动物研究中纤维肌痛患者持续疼痛的潜在机制。纤维肌痛患者中枢神经系统伤害性处理的改变有大量的支持，心理因素如压力可以增强疼痛体验。新出现的证据已经开始探索其他潜在的机制，包括外周神经系统成分产生疼痛和全身炎症的作用。我们将探讨的数据和神经生物学相关的中枢神经系统的作用，在伤害性处理，然后通过一个简短的审查研究检查潜在的外周神经系统的变化和细胞因子的参与。我们不仅将探索来自纤维肌痛人类受试者的数据，而且将其与纤维肌痛动物模型的发现相关联。我们的结论是，纤维肌痛和相关疾病是异质性条件与复杂的病理生物学与患者下降沿着一个连续体，一端是一个纯粹的外周驱动的疼痛条件和连续体的另一端是当疼痛是纯粹的中央驱动。
Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified. The underlying mechanisms, in both human and animal studies, for the continued pain in individuals with fibromyalgia will be explored in this review. There is a substantial amount of support for alterations of central nervous system nociceptive processing in people with fibromyalgia, and that psychological factors such as stress can enhance the pain experience. Emerging evidence has begun exploring other potential mechanisms including a peripheral nervous system component to the generation of pain and the role of systemic inflammation. We will explore the data and neurobiology related to the role of the CNS in nociceptive processing, followed by a short review of studies examining potential peripheral nervous system changes and cytokine involvement. We will not only explore the data from human subjects with fibromyalgia but will relate this to findings from animal models of fibromyalgia. We conclude that fibromyalgia and related disorders are heterogenous conditions with a complicated pathobiology with patients falling along a continuum with one end a purely peripherally driven painful condition and the other end of the continuum is when pain is purely centrally driven.
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DOI：
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发表时间：
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通讯作者：
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