Addressing variability in the acoustic startle reflex for accurate gap detection assessment.
Addressing variability in the acoustic startle reflex for accurate gap detection assessment.
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DOI：
10.1016/j.heares.2018.03.013
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发表时间：
2018-06
期刊：
影响因子：
2.8
通讯作者：
Galazyuk AV
中科院分区：
文献类型：
--
作者：
Longenecker RJ;Kristaponyte I;Nelson GL;Young JW;Galazyuk AV
声惊吓反射（ASR）具有很大的变异性。因此，这种固有的变异性形成了从声惊吓反射（GPIAS）评估的间隙诱导的前脉冲抑制中得出的结论。最近的研究对这种方法的有效性表示怀疑，因为它涉及耳鸣评估，部分原因是数据集之间的差异。本研究的目的是检查与几个常见的数据收集变量和数据分析，旨在提高GPIAS的可靠性的方差。为了研究这一点，在成年雄性和雌性CBA/CaJ小鼠中进行GPIAS测试。每个因素，如试验间隔，昼夜节律，性别差异和感觉适应进行了评估。然后，我们研究了影响GPIAS评估的各种数据分析因素。间隙诱导的促进，数据处理选项，耳鸣的评估进行了研究。我们发现，CBA/CaJ小鼠的惊吓反射是高度可变的，但这可以通过某些数据收集因素最小化。我们还发现，仔细考虑ASR的时间波动和控制易化可能会导致GPIAS结果大相径庭。最后，我们表明，耳鸣减少间隙引起的抑制声惊吓反射，但只有很短的间隙持续时间。这项研究为减少GPIAS方法的方差提供了指导-从而提高了测试的诊断能力。
The acoustic startle reflex (ASR) is subject to substantial variability. This inherent variability consequently shapes the conclusions drawn from gap-induced prepulse inhibition of the acoustic startle reflex (GPIAS) assessments. Recent studies have cast doubt as to the efficacy of this methodology as it pertains to tinnitus assessment, partially, due to variability in and between data sets. The goal of this study was to examine the variance associated with several common data collection variables and data analyses with the aim to improve GPIAS reliability. To study this the GPIAS tests were conducted in adult male and female CBA/CaJ mice. Factors such as inter-trial interval, circadian rhythm, sex differences, and sensory adaptation were each evaluated. We then examined various data analysis factors which influence GPIAS assessment. Gap-induced facilitation, data processing options, and assessments of tinnitus were studied. We found that the startle reflex is highly variable in CBA/CaJ mice, but that this can be minimized by certain data collection factors. We also found that careful consideration of temporal fluctuations of the ASR and controlling for facilitation can lead to drastically divergent GPIAS results. Finally, we show that tinnitus decreases gap-induced inhibition of the acoustic startle reflex, but only for short gap durations. This study provides a guide for reducing variance in the GPIAS methodology – thereby improving the diagnostic power of the test.
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