Force Spectroscopy and Beyond: Innovations and Opportunities.
Force Spectroscopy and Beyond: Innovations and Opportunities.
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DOI：
10.1016/j.bpj.2018.10.021
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发表时间：
2018-12-18
影响因子：
3.4
通讯作者：
Wong WP
中科院分区：
文献类型：
--
作者：
Nathwani B;Shih WM;Wong WP
Life operates at the intersection of chemistry and mechanics. Over the years, we have made remarkable progress in understanding life from a biochemical perspective and the mechanics of life at the single-molecule scale. Yet the full integration of physical and mechanical models into mainstream biology has been impeded by technical and conceptual barriers, including limitations in our ability to 1) easily measure and apply mechanical forces to biological systems, 2) scale these measurements from single-molecule characterization to more complex biomolecular systems, and 3) model and interpret biophysical data in a coherent way across length scales that span single molecules to cells to multicellular organisms. In this manuscript, through a look at historical and recent developments in force spectroscopy techniques and a discussion of a few exemplary open problems in cellular biomechanics, we aim to identify research opportunities that will help us reach our goal of a more complete and integrated understanding of the role of force and mechanics in biological systems.
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影响因子：
12.3
作者：
Carpenter AE;Jones TR;Lamprecht MR;Clarke C;Kang IH;Friman O;Guertin DA;Chang JH;Lindquist RA;Moffat J;Golland P;Sabatini DM
通讯作者：
Sabatini DM
影响因子：
16.6
作者：
Cavusoglu AH;Chen X;Gentine P;Sahin O
通讯作者：
Sahin O
影响因子：
3.4
作者：
Evans, E;Ritchie, K
通讯作者：
Ritchie, K
DOI：
10.1073/pnas.1705179114
发表时间：
2017-10-10
影响因子：
11.1
作者：
Guo, Ming;Pegoraro, Adrian F.;Weitz, David A.
通讯作者：
Weitz, David A.
影响因子：
3.4
作者：
Halvorsen, Ken;Wong, Wesley P.
通讯作者：
Wong, Wesley P.