MicroRNAs: control and loss of control in human physiology and disease.
MicroRNAs: control and loss of control in human physiology and disease.
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DOI：
10.1007/s00268-008-9836-x
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发表时间：
2009-04
影响因子：
2.6
通讯作者：
Chen, Changyi
中科院分区：
文献类型：
--
作者：
Li, Min;Marin-Muller, Christian;Bharadwaj, Uddalak;Chow, Kwong-Hon;Yao, Qizhi;Chen, Changyi
对人类基因组的分析表明，大部分基因组序列是不编码任何蛋白质的RNA，也称为非编码RNA。MicroRNA（miRNAs）是一类长度为20-22个核苷酸的非编码RNA小分子，控制着哺乳动物中约30%的蛋白质编码基因的活性。miRNAs在许多疾病中发挥重要作用，包括癌症、心血管疾病和免疫紊乱。miRNAs的表达可以通过表观遗传修饰、DNA拷贝数改变和基因突变来调节。miRNA可以作为许多疾病的有价值的治疗靶点。对于具有致癌能力的miRNA，潜在的疗法包括miRNA沉默、反义阻断和miRNA修饰。对于具有肿瘤抑制功能的miRNAs，过表达这些miRNAs可能是抑制肿瘤生长的有用策略。本文就miRNA的研究进展、miRNA的表达调控、miRNA作用靶点的预测以及miRNA在人体生理和疾病中的调控作用进行综述，重点介绍了miRNA在胰腺癌、肝癌、结肠直肠癌、心血管疾病、免疫系统和感染性疾病中的作用。这篇综述为临床医生和研究人员提供了有价值的信息，他们希望认识到这一新领域的最新进展，并确定miRNA作为人类生理学和疾病中重要介质的可能研究路线。
Analysis of the human genome indicated that a large fraction of the genome sequences are RNAs that do not encode any proteins, also known as non-coding RNAs. MicroRNAs (miRNAs) are a group of small non-coding RNA molecules, with 20–22-nucleotide (nt) in length, and are predicted to control the activity of approximately 30% of all protein-coding genes in mammals. miRNAs play important roles in many diseases including cancer, cardiovascular disease, and immune disorders. The expression of miRNAs can be regulated by epigenetic modification, DNA copy number change, and genetic mutations. miRNAs can serve as a valuable therapeutic target for a large number of diseases. For miRNAs with oncogenic capabilities, potential therapies include miRNA silencing, antisense blocking, and miRNA modifications. For miRNAs with tumor suppression functions, over-expression of those miRNAs might be a useful strategy to inhibit tumor growth. In this review, we discuss the current progress of miRNA research, regulation of miRNA expression, prediction of miRNA targets, and regulatory role of miRNAs in human physiology and diseases, with a specific focus on miRNAs in pancreatic cancer, liver cancer, colon rectal cancer, cardiovascular disease, immune system, and infectious disease. This review provides valuable information for clinicians and researchers who want to recognize the newest advances in this new field and identify possible lines of investigation in miRNAs as important mediators in human physiology and diseases.
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DOI：
10.1084/jem.20061692
发表时间：
2006-10-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cobb BS;Hertweck A;Smith J;O'Connor E;Graf D;Cook T;Smale ST;Sakaguchi S;Livesey FJ;Fisher AG;Merkenschlager M
通讯作者：
Merkenschlager M
DOI：
10.1073/pnas.0800121105
发表时间：
2008-04-01
影响因子：
11.1
作者：
Calin, George A.;Cimmino, Amelia;Croce, Carlo M.
通讯作者：
Croce, Carlo M.
影响因子：
30.8
作者：
Bentwich, I;Avniel, A;Bentwich, Z
通讯作者：
Bentwich, Z
影响因子：
14.9
作者：
Betel D;Wilson M;Gabow A;Marks DS;Sander C
通讯作者：
Sander C
影响因子：
12.4
作者：
Bu, LM;Bradley, M;Nordenskjold, M
通讯作者：
Nordenskjold, M