C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses.
C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses.
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DOI：
10.1016/j.immuni.2014.09.009
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发表时间：
2014-10-16
期刊：
影响因子：
32.4
通讯作者：
Oh, SangKon
中科院分区：
文献类型：
--
作者：
Joo, HyeMee;Li, Dapeng;Dullaers, Melissa;Kim, Tae-Whan;Duluc, Dorothee;Upchurch, Katherine;Xue, Yaming;Zurawski, Sandy;Le Grand, Roger;Liu, Yong-Jun;Kuroda, Marcelo;Zurawski, Gerard;Oh, SangKon
凝集素样氧化低密度脂蛋白受体-1（LOX-1）是多种内源性和外源性配体的模式识别受体。然而，LOX-1在宿主免疫应答中的功能尚未完全了解。在这里，我们报告LOX-1表达的树突状细胞（DC）和B细胞促进体液反应。在B细胞上，LOX-1信号上调CCR 7，促进细胞向淋巴组织迁移。DC上的LOX-1信号允许细胞促进B细胞分化为类别转换的浆母细胞，并导致浆母细胞上的趋化因子受体CXCR 5下调和趋化因子受体CCR 10上调，这使得它们能够离开生殖中心并向局部粘膜和皮肤迁移。最后，我们发现，针对流感血凝素1（HA 1）亚基LOX-1引起HA 1特异性保护性抗体反应的恒河猴。因此，在B细胞和DC细胞上表达的LOX-1具有促进体液免疫应答的互补功能。
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a pattern recognition receptor for a variety of endogenous and exogenous ligands. However, LOX-1 function in the host immune response is not fully understood. Here, we report that LOX-1 expressed on dendritic cells (DCs) and B cells promotes humoral responses. On B cells LOX-1 signaling upregulated CCR7, promoting cellular migration towards lymphoid tissues. LOX-1 signaling on DCs licensed the cells to promote B cell differentiation into class-switched plasmablasts, and led to downregulation of chemokine receptor CXCR5 and upregulation of chemokine receptor CCR10 on plasmablasts, which enabled their exit from germinal centers and migration towards local mucosa and skin. Finally, we found that targeting influenza hemagglutinin 1 (HA1) subunit to LOX-1 elicited HA1-specific protective antibody responses in rhesus macaques. Thus, LOX-1 expressed on B cells and DC cells has complementary functions to promote humoral immune responses.
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DOI：
10.1038/nri2569
发表时间：
2009-07
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Geijtenbeek TB;Gringhuis SI
通讯作者：
Gringhuis SI
影响因子：
15.3
作者：
Bowman, E P;Campbell, J J;Soler, D;Dong, Z;Manlongat, N;Picarella, D;Hardy, R R;Butcher, E C
通讯作者：
Butcher, E C
DOI：
10.4049/jimmunol.1301661
发表时间：
2014-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Duluc D;Joo H;Ni L;Yin W;Upchurch K;Li D;Xue Y;Klucar P;Zurawski S;Zurawski G;Oh S
通讯作者：
Oh S
影响因子：
56.9
作者：
ARPIN, C;DECHANET, J;LIU, YJ
通讯作者：
LIU, YJ
影响因子：
3.5
作者：
Bassi, N.;Zampieri, S.;Doria, A.
通讯作者：
Doria, A.