Distinctive types of aversiveness are represented as the same in a portion of the dorsal anterior cingulate cortex: An fMRI study with the cue paradigm
Distinctive types of aversiveness are represented as the same in a portion of the dorsal anterior cingulate cortex: An fMRI study with the cue paradigm
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不同类型的厌恶在背侧前扣带皮层的一部分中表现得相同：使用线索范式的功能磁共振成像研究
DOI：
10.1016/j.neuroscience.2022.09.001
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发表时间：
2022
期刊：
影响因子：
3.3
通讯作者：
Haruno Masahiko
中科院分区：
文献类型：
--
作者：
Minamoto Takehiro;Haruno Masahiko
一些研究认为，背侧前扣带皮层（dACC）通常在对厌恶信息（包括疼痛，负面影响和认知冲突）做出反应时被激活。其他研究声称，dACC有细分，每个部门都有特定的功能。通过操纵情绪和认知上的厌恶线索，本研究确定了dACC是否对厌恶有普遍的反应，或者它对特定形式的厌恶有细分。连接功能磁共振成像（fMRI）分析表明，情绪和认知上的厌恶线索激活了dACC的同一部分。当这些线索被连续呈现时，该区域表现出相加活性，进一步支持了dACC中两种不同形式的厌恶的重叠表示。额外的有效连接分析表明，dACC与不同的大脑区域共同激活，这取决于线索类型，表征了其行为控制机制。互补的多变量分析表明，反应时间与dACC的活动呈负相关，情绪线索下的dACC的活动预测的个人状态焦虑评分，但不下的认知线索。我们还发现，dACC的上级部分是唯一激活的认知厌恶的线索，部分支持功能分离帐户。总的来说，我们的研究结果提供的证据表明，特定的位点的dACC通常是响应独特的动机信息，而其他位点可能有隔离的功能。讨论包括最近的神经计算理论，似乎令人满意地占目前的结果。
Some studies have argued that the dorsal anterior cingulate cortex (dACC) is generally activated in response to aversive information, including pain, negative affect, and cognitive conflict. Other studies have claimed that the dACC has subdivisions, and each division has a specific function. By manipulating emotionally and cognitively aversive cues, the present study determined whether the dACC is generally responsive to aversiveness or it has subdivisions for specific forms of aversiveness. Conjunction functional magnetic resonance imaging (fMRI) analysis showed that emotionally and cognitively aversive cues activated the same portion of the dACC. When these cues were contiguously presented, the region demonstrated additive activity, further supporting the overlapping representation of the two different forms of aversiveness in the dACC. Additional effective connectivity analysis showed that the dACC was co-activated with different brain regions depending on the cue type, characterizing its behavioral control mechanism. Complementary multivariate analyses showed that the reaction time was negatively correlated with the activity of the dACC and that the activity of the dACC under the emotional cue was predicted by the individual state anxiety score but not under the cognitive cue. We also found that the superior part of the dACC was uniquely activated in response to cognitively aversive cues, partially supporting the functional segregation account. Collectively, our results provide evidence that the specific locus of the dACC is generally responsive to distinctive motivational information, whereas the other loci may have segregated functions. Discussion includes recent neurocomputational theories that seem to satisfactorily account for the present results.
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