Non-nutritive sweeteners: no class effect on the glycaemic or appetite responses to ingested glucose.
Non-nutritive sweeteners: no class effect on the glycaemic or appetite responses to ingested glucose.
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DOI：
10.1038/ejcn.2014.19
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发表时间：
2014-05
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
人们对非营养性甜味剂是否在胃肠道中被感知以调节对摄入的碳水化合物的食欲或吸收反应有相当大的兴趣。我们确定了一组非营养性甜味剂的效果，如糖精，糖精和安赛蜜-K，以正常使用的剂量提供。每一种都与葡萄糖联合给药，评估它们对10名健康人类受试者的血糖反应和食欲的影响。在任何时间点，尽管安赛蜜-K对口服葡萄糖的血糖反应有很小的影响，但安赛蜜或糖精对血糖反应没有额外的影响。然而，没有一个对饥饿或饱腹感有影响。我们的结论是，没有一致的证据表明，非营养甜味剂，当急性消耗与葡萄糖在饮食相关的剂量，在调节血糖在健康的人类受试者的类效应。然而，安赛蜜-K可能需要进一步探索。
There is considerable interest in whether non-nutritive sweeteners are sensed in the gastrointestinal tract to modulate appetitive or absorptive responses to ingested carbohydrate. We determined the effect of a panel of non-nutritive sweeteners, aspartame, saccharin and acesulfame-K, delivered in doses that would be consumed in normal usage. Each was given in combination with glucose, assessing their effect on glycemic responses and appetite in ten healthy human subjects. There was no additional effect of aspartame or saccharin on the blood glucose response to oral glucose at any time point, although acesulfame-K exerted a small effect. However, none had an effect on perceptions of hunger or fullness. We conclude that there is no consistent evidence that non-nutrient sweeteners, when acutely consumed with glucose in dietetically relevant doses, have a class effect in modulating blood glucose in healthy human subjects. However, acesulfame-K may require further exploration.
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发表时间：
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