A novel method of evaluating semantic intrusion errors to distinguish between amyloid positive and negative groups on the Alzheimer's disease continuum.
A novel method of evaluating semantic intrusion errors to distinguish between amyloid positive and negative groups on the Alzheimer's disease continuum.
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DOI：
10.1016/j.jpsychires.2020.02.008
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发表时间：
2020-05
影响因子：
4.8
通讯作者：
Loewenstein, David A.
中科院分区：
文献类型：
--
作者：
Cid, Rosie E. Curiel;Crocco, Elizabeth A.;Duara, Ranjan;Garcia, Jessica M.;Rosselli, Monica;DeKosky, Steven T.;Smith, Glenn;Bauer, Russell;Chirinos, Cesar L.;Adjouadi, Malek;Barker, Warren;Loewenstein, David A.
关键词：
开发和验证临床结果指标以检测与阿尔茨海默病（AD）生物标志物相关的早期认知能力下降势在必行。作为 AD 前驱期脑淀粉样蛋白升高的早期相关因素，Loewenstein Acevedo 语义干扰和学习量表 (LASSI-L) 的语义侵入优于广泛使用的认知测量，并区分了患有遗忘性轻度认知障碍 (aMCI) 和高淀粉样蛋白负荷的患者与其他非 AD 病症所致的 aMCI。由于记忆任务中的入侵错误差异很大，我们采用了一种新颖的方法来计算入侵错误（PIE）相对于总响应的百分比。研究人员对 aMCI 和痴呆谱系中淀粉样蛋白负荷高或低的个体以及淀粉样蛋白阴性、认知正常的老年人 (CN) 进行了研究。对主动语义干扰 (PSI) 敏感的指数的平均 PIE 和无法从主动语义干扰 (frPSI) 中恢复的指标可以区分淀粉样蛋白阳性与淀粉样蛋白阴性 aMCI 和痴呆组。仅凭正确反应的数量，虽然能够区分不同的诊断组，但并不能将淀粉样蛋白阳性 aMCI 与无淀粉样蛋白病理的对应物区分开来。 PIE 是一种新颖且敏感的早期记忆功能障碍指标，在区分 CN 与患有临床前 AD 的淀粉样蛋白阳性患者方面表现出高水平的敏感性和特异性。淀粉样蛋白阳性 aMCI 和痴呆症参与者的 PIE 平均水平高于淀粉样蛋白阴性参与者。
The development and validation of clinical outcome measures to detect early cognitive decline associated with Alzheimer’s disease (AD) biomarkers is imperative. Semantic intrusions on the Loewenstein Acevedo Scales of Semantic Interference and Learning (LASSI-L) has outperformed widely used cognitive measures as an early correlate of elevated brain amyloid in prodromal AD and has distinguished those with amnestic mild cognitive impairment (aMCI) and high amyloid load from aMCI attributable to other non-AD conditions. Since intrusion errors on memory tasks vary widely, we employed a novel method that accounts for the percentage of intrusion errors (PIE) in relation to total responses. Individuals with either high or low amyloid load across the spectrum of aMCI and dementia and amyloid negative cognitively normal older adults (CN) were studied. Mean PIE on indices sensitive to proactive semantic interference (PSI) and failure to recover from proactive semantic interference (frPSI) could distinguish amyloid positive from amyloid negative aMCI and dementia groups. Number of correct responses alone, while able to differentiate the different diagnostic groups, did not differentiate amyloid positive aMCI from their counterparts without amyloid pathology. PIE, a novel and sensitive index of early memory dysfunction, demonstrated high levels of sensitivity and specificity in differentiating CN from amyloid positive persons with preclinical AD. Mean levels of PIE are higher for amyloid positive aMCI and dementia participants relative to their amyloid negative counterparts.
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影响因子：
48
作者：
Rowe, Christopher C.;Ackerman, Uwe;Villemagne, Victor L.
通讯作者：
Villemagne, Victor L.
影响因子：
3.2
作者：
Lizarraga, Gabriel;Li, Chunfei;Adjouadi, Malek
通讯作者：
Adjouadi, Malek
用于检测社区老年人轻度认知障碍的简短计算机配对测试。
DOI：
10.3233/jad-160370
发表时间：
2016-09-06
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Curiel RE;Crocco E;Rosado M;Duara R;Greig MT;Raffo A;Loewenstein DA
通讯作者：
Loewenstein DA
影响因子：
11.1
作者：
Petersen RC;Caracciolo B;Brayne C;Gauthier S;Jelic V;Fratiglioni L
通讯作者：
Fratiglioni L
影响因子：
14
作者：
Benson, Gloria;de Felipe, Jesus;Sano, Mary
通讯作者：
Sano, Mary