Maintaining Transcriptional Specificity Through Mitosis.
Maintaining Transcriptional Specificity Through Mitosis.
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通过有丝分裂维持转录特异性。
DOI：
10.1146/annurev-genom-121321-094603
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发表时间：
2022-08-31
影响因子：
8.7
通讯作者：
中科院分区：
文献类型：
--
作者：
几乎所有的细胞类型都有相同的DNA，但每种细胞类型都表现出自己的细胞特异性基因表达模式。在有丝分裂的短暂时期，染色体表现出蛋白质组成和修饰的变化，明显的凝结，随之而来的转录减少。然而，当细胞退出有丝分裂时，它们以高保真度重新激活它们的细胞特异性程序。最初，该领域专注于有丝分裂中选择性保留在染色质中并因此“书签”的转录因子子集。然而，最近的研究表明，许多转录因子可以保留在有丝分裂染色质中，令人惊讶的是，这种保留可能是由于非特异性染色质结合。在此，我们回顾了通过启动子而不是增强子进行低水平转录的最新研究，以及对染色体结构动力学、组蛋白修饰、细胞周期信号传导和核包膜蛋白的新见解，这些新见解共同确保了基因在有丝分裂过程中的表达保真度。
Virtually all cell types have the same DNA, yet each cell type exhibits its own cell-specific pattern of gene expression. During the brief period of mitosis, the chromosomes exhibit changes in protein composition and modifications, a marked condensation, a consequent reduction in transcription. Yet as cells exit mitosis, they re-activate their cell-specific programs with high fidelity. Initially, the field focused on the subset of transcription factors that are selectively retained in, and hence “bookmark,” chromatin in mitosis. However, recent studies show that many transcription factors can be retained in mitotic chromatin and that, surprisingly, such retention can be due to non-specific chromatin binding. Here we review the latest studies focusing on low-level transcription via promoters, rather than enhancers, as contributing to mitotic memory, as well as new insights into chromosome structure dynamics, histone modifications, cell cycle signaling, and nuclear envelope proteins that together ensure the fidelity of gene expression through a round of mitosis.
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影响因子：
11.8
作者：
Chen, Chin-Chi;Bowers, Sarion;Lipinszki, Zoltan;Palladino, Jason;Trusiak, Sarah;Bettini, Emily;Rosin, Leah;Przewloka, Marcin R.;Glover, David M.;O'Neill, Rachel J.;Mellone, Barbara G.
通讯作者：
Mellone, Barbara G.
影响因子：
16
作者：
Dou, YL;Mizzen, CA;Gorovsky, MA
通讯作者：
Gorovsky, MA
影响因子：
64.5
作者：
Bonev B;Mendelson Cohen N;Szabo Q;Fritsch L;Papadopoulos GL;Lubling Y;Xu X;Lv X;Hugnot JP;Tanay A;Cavalli G
通讯作者：
Cavalli G
影响因子：
16
作者：
Blobel GA;Kadauke S;Wang E;Lau AW;Zuber J;Chou MM;Vakoc CR
通讯作者：
Vakoc CR
影响因子：
9.3
作者：
Chen SY;Osimiri LC;Chevalier M;Bugaj LJ;Nguyen TH;Greenstein RA;Ng AH;Stewart-Ornstein J;Neves LT;El-Samad H
通讯作者：
El-Samad H