The value of serum p53 antibody as a biomarker in oral and pharyngeal squamous cell carcinoma
The value of serum p53 antibody as a biomarker in oral and pharyngeal squamous cell carcinoma
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血清p53抗体作为口咽鳞状细胞癌生物标志物的价值
DOI：
10.1080/00016489.2023.2165144
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发表时间：
2023
影响因子：
1.4
通讯作者：
Shiotani Akihiro
中科院分区：
文献类型：
--
作者：
Hirokawa Shotaro;Araki Koji;Yamashita Taku;Uno Kosuke;Tomifuji Masayuki;Shimada Hideaki;Shiotani Akihiro
本研究旨在探讨血清p53抗体在头颈部鳞状细胞癌早期诊断中的价值，为临床早期诊断提供新的方法材料与方法收集71例口腔咽癌患者和117例健康志愿者的治疗前血清，分析s-p53-Ab作为口腔咽癌的生物标志物。结果以1.3U/mL为临界值，71例患者中有14例（敏感性19.7%）和117例对照中有12例s-p53-Ab阳性（特异性89.7%）。除1 - 2例p16阳性的口咽癌和鼻咽癌均为s-p53-Ab阴性外，早期1-2期的敏感性为30.0%，高于常规肿瘤标志物。由于s-p53-Ab的敏感性高，即使在早期疾病，s-p53-Ab测量可能是有用的，作为一个早期诊断的生物标志物在口腔癌，p16-口咽癌，下咽癌患者。
BackgroundThe development of more sensitive biomarkers for the detection of early-stage head and neck squamous cell carcinoma is needed.Aims/ObjectivesThis study was performed to assess the value of serum p53 antibody (s-p53-Ab) as a biomarker for oral and pharyngeal carcinoma.Material and MethodsPre-treatment serum was collected for 71 patients with oral and pharyngeal carcinoma and 117 healthy volunteers as controls and analyzed s-p53-Ab using enzyme-linked immunosorbent assay (ELISA).ResultsUsing 1.3 U/mL as the cut-off value, 14 of 71 patients (sensitivity 19.7%), and 12 of 117 control cases were positive for s-p53-Ab (specificity 89.7%). Excluding 12 cases of p16-positive oropharyngeal and nasopharyngeal cancer which were all negative for s-p53-Ab, the sensitivity in early-stage 1–2 cases was 30.0%, which was higher than conventional tumor markers.Conclusions and SignificanceThe s-p53-Ab was not detected in any cases of virus-related cancer in which p53 gene mutations were not involved in carcinogenesis. Since the s-p53-Ab sensitivity was high even in early-stage disease, s-p53-Ab measurement may be useful as an early diagnostic biomarker in patients with oral, p16- oropharyngeal, and hypopharyngeal cancer.
影响因子：
158.5
作者：
Poeta, M. Luana;Manola, Judith;Koch, Wayne M.
通讯作者：
Koch, Wayne M.
头颈癌新的预后指标——p53血清抗体？
影响因子：
2
作者：
S. Gottschlich;Benedikt J. Folz;T. Goeroegh;B. M. Lippert;J. Maass;Jochen A. Werner
通讯作者：
Jochen A. Werner
影响因子：
2.4
作者：
Suzuki, Takashi;Yajima, Satoshi;Shimada, Hideaki
通讯作者：
Shimada, Hideaki