Choose your path: Divergent basolateral amygdala efferents differentially mediate incentive motivation, flexibility and decision-making.
Choose your path: Divergent basolateral amygdala efferents differentially mediate incentive motivation, flexibility and decision-making.
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DOI：
10.1016/j.bbr.2021.113306
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发表时间：
2021-07-09
影响因子：
2.7
通讯作者：
Calu DJ
中科院分区：
文献类型：
--
作者：
Keefer SE;Gyawali U;Calu DJ
为了在复杂的环境中生存，个体在环境刺激和奖励之间形成联系，以组织和优化奖励寻求行为。杏仁基底外侧核(BLA)使用这些习得的联系来为决策过程提供信息。在这篇综述中，我们描述了BLA与其皮质和纹状体目标之间的功能投射，这些投射促进了决策中心的学习和动机过程。具体地说，我们比较和对比了从BLA到眶前额核(OFC)和伏隔核(NAC)的不同投射，并研究了这些通路在联想学习、价值导向决策、选择行为以及线索和上下文驱动的药物寻找中的作用。最后，我们考虑这些投射是如何参与动机障碍的，重点是物质使用障碍。
To survive in a complex environment, individuals form associations between environmental stimuli and rewards to organize and optimize reward seeking behaviors. The basolateral amygdala (BLA) uses these learned associations to inform decision-making processes. In this review, we describe functional projections between BLA and its cortical and striatal targets that promote learning and motivational processes central to decision-making. Specifically, we compare and contrast divergent projections from the BLA to the orbitofrontal (OFC) and to the nucleus accumbens (NAc) and examine the roles of these pathways in associative learning, value-guided decision-making, choice behaviors, as well as cue and context-driven drug seeking. Finally, we consider how these projections are involved in disorders of motivation, with a focus on Substance Use Disorder.
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影响因子：
7.6
作者：
Arguello, Amy A.;Richardson, Ben D.;Fuchs, Rita A.
通讯作者：
Fuchs, Rita A.
影响因子：
2.8
作者：
Brebner, K;Childress, AR;Roberts, DCS
通讯作者：
Roberts, DCS
影响因子：
64.8
作者：
Burke, Kathryn A.;Franz, Theresa M.;Schoenbaum, Geoffrey
通讯作者：
Schoenbaum, Geoffrey
DOI：
10.1111/ejn.12278
发表时间：
2013-09
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Chaudhri N;Woods CA;Sahuque LL;Gill TM;Janak PH
通讯作者：
Janak PH
影响因子：
16.4
作者：
Berridge, Kent C.;Robinson, Terry E.
通讯作者：
Robinson, Terry E.