Insulin resistance, age and depression's impact on cognition in middle-aged adults from the PREVENT cohort.
Insulin resistance, age and depression's impact on cognition in middle-aged adults from the PREVENT cohort.
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DOI：
10.1136/bmjment-2023-300665
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发表时间：
2023-05
期刊：
影响因子：
--
通讯作者：
Koychev, Ivan
中科院分区：
文献类型：
--
作者：
Bauermeister, Sarah D.;Ben Yehuda, Michael;Reid, Graham;Howgego, Gregory;Ritchie, Karen;Watermeyer, Tam;Gregory, Sarah;Terrera, Graciela Muniz;Koychev, Ivan
阿尔茨海默病（AD）、2型糖尿病（以胰岛素抵抗为特征）和抑郁症是公共卫生面临的重大挑战。研究已经证明了这三种疾病中常见的合并症，通常一次关注其中两种。然而，这项研究的目的是评估这三种疾病之间的相互关系，重点是在AD引起的痴呆症出现之前的中年（定义为40-59岁）风险。在目前的研究中，我们使用了来自队列研究PREVENT的665名参与者的横断面数据。使用结构方程模型，我们表明：（1）胰岛素抵抗预测中年老年人而不是年轻人的执行功能障碍，（2）胰岛素抵抗预测老年人和年轻中年人自我报告的抑郁症，（3）抑郁症预测中年老年人而不是年轻人的视觉空间记忆缺陷。我们一起展示了中年人三种常见非传染性疾病之间的相互关系。我们强调需要综合干预和利用资源来帮助中年人改变认知障碍的危险因素，如抑郁症和糖尿病。
Alzheimer’s disease (AD), type 2 diabetes mellitus (characterised by insulin resistance) and depression are significant challenges facing public health. Research has demonstrated common comorbidities among these three conditions, typically focusing on two of them at a time. The goal of this study, however, was to assess the inter-relationships between the three conditions, focusing on mid-life (defined as age 40–59) risk before the emergence of dementia caused by AD. In the current study, we used cross-sectional data from 665 participants from the cohort study, PREVENT. Using structural equation modelling, we showed that (1) insulin resistance predicts executive dysfunction in older but not younger adults in mid-life, that (2) insulin resistance predicts self-reported depression in both older and younger middle-aged adults and that (3) depression predicts deficits in visuospatial memory in older but not younger adults in mid-life. Together, we demonstrate the inter-relations between three common non-communicable diseases in middle-aged adults. We emphasise the need for combined interventions and the use of resources to help adults in mid-life to modify risk factors for cognitive impairment, such as depression and diabetes.
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影响因子：
4.6
作者：
Amunts J;Camilleri JA;Eickhoff SB;Patil KR;Heim S;von Polier GG;Weis S
通讯作者：
Weis S
DOI：
10.1038/nrneurol.2017.185
发表时间：
2018-03
期刊：
Nature reviews. Neurology
影响因子：
--
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影响因子：
120.7
作者：
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通讯作者：
Lyketsos, Constantine